Author

A. K. Jayabalan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:virus· 1

Frequent Co-Authors

A. Leung· 2 shared A. G. Thomas· 1 shared A. K. L. Leung· 1 shared B. Murphy· 1 shared B. S. Slusher· 1 shared D. E. Griffin· 1 shared J. A. Goodman· 1 shared J. Bosch· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

A. Leung

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Author profile →

3 papers

Recent·Most cited

PARP10 is Critical for Stress Granule Initiation

A. k. Jayabalan, K. Bhambhani, A. Leung

This study identifies PARP10 as essential for stress granule initiation, showing it regulates assembly kinetics and modifies G3BP1 to influence SG composition.

bioRxiv · Oct 13, 2023Cell Biology

High-throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain

M. A. Dasovich, J. Zhuo, A. G. Thomas, J. A. Goodman, R. L. McPherson, A. K. Jayabalan, V. F. Busa, S.-J. Cheng, B. Murphy, K. R. Redinger, T. Tsukamoto, B. S. Slusher, J. Bosch, J. Wei, A. Leung

The paper develops a high-throughput assay for screening inhibitors of the SARS-CoV-2 Mac1 macrodomain and identifies dasatinib and dihydralazine as inhibitors with selectivity over human MacroD2.

bioRxiv · Oct 7, 2021Biochemistry

Alphavirus nsP3 ADP-ribosylhydrolase Activity Disrupts Stress Granule Formation

A. K. Jayabalan, D. E. Griffin, A. K. L. Leung

This study shows that alphavirus nsP3 disrupts stress granule formation by removing ADP-ribosylation from G3BP1 and altering translation factor localization.

bioRxiv · Jun 20, 2019 · PreprintCell Biology