K. Koeppen

P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis

This paper shows tobramycin reduces inflammation in cystic fibrosis by increasing 5' tRNA-fMet halves in P. aeruginosa outer membrane vesicles, which suppress IL-8 and neutrophilic inflammation in human cells and mice.

Systemic Sclerosis dermal fibroblast exosomes trigger a Type 1 interferon response in keratinocytes through the TBK/JAK/STAT signalling axis

An rRNA fragment in extracellular vesicles secreted by human airway epithelial cells increases the fluoroquinolone sensitivity of P. aeruginosa

This study identifies an rRNA fragment from human airway epithelial cell extracellular vesicles that enhances P. aeruginosa sensitivity to ciprofloxacin by downregulating the MexHI-OpmD efflux pump.

Tobramycin-induced secretion of P. aeruginosa 5' tRNA-fMet halves suppresses lung inflammation via AGO2 gene silencing

This study shows tobramycin reduces lung inflammation in pwCF by increasing 5' tRNA-fMet halves that suppress IL-8 and neutrophil recruitment via AGO2 gene silencing.

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway

This study identifies Ssn3 kinase substrates involved in hyphal growth repression through Flo8 phosphorylation in C. albicans.

Conditional antagonism in co-cultures of Pseudomonas aeruginosa and Candida albicans: an intersection of ethanol and phosphate signaling distilled from dual-seq transcriptomics

This study identifies ethanol and phosphate signaling interactions between Pseudomonas aeruginosa and Candida albicans using dual RNA-seq, revealing conditional antagonism mediated by PhoB and Pho4.