Author

P. R. Secor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 11

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 7 Research Focus:cell type annotation· 5 Organism:human· 5 Assay:proteomics· 5 Organism:bacteria (other)· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

C. M. Schwartzkopf· 4 shared D. M. Brooks· 4 shared D. R. Faith· 4 shared M. Kinnersley· 3 shared P. L. Bollyky· 3 shared A. Hargil· 2 shared A. J. Robinson· 2 shared A. Joyce· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMicrobiology

C. M. Schwartzkopf

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11 papers

Recent·Most cited

Characterization and genomic analysis of the Lyme disease spirochete bacteriophage phiBB-1

D. R. Faith, M. Kinnersley, D. M. Brooks, D. Drecktrah, L. S. Hall, E. Luo, A. Santiago-Frangos, J. Wachter, S. Samuels, P. R. Secor

This study characterizes the bacteriophage phiBB-1 using proteomics and long-read sequencing, revealing its packaging mechanisms and role in gene transfer in Borrelia burgdorferi.

PLOS Pathogens · Apr 1, 2024Peer-reviewedMicrobiology

Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding

Q. Chen, P. Cai, T. H. W. Chang, E. Burgener, M. J. Kratochvil, A. Gupta, A. Hargil, P. R. Secor, J. E. Nielsen, A. E. Barron, C. Milla, S. C. Heilshorn, A. J. Spakowitz, P. L. Bollyky

This study shows Pf phages and sputum polymers reduce antibiotic diffusion through electrostatic binding and liquid crystal formation in chronic Pseudomonas aeruginosa infections.

bioRxiv · Mar 10, 2024 · PreprintMicrobiology

Targeted deletion of Pf prophages from diverse Pseudomonas aeruginosa isolates impacts quorum sensing and virulence traits

A. K. Schmidt, C. M. Schwartzkopf, J. D. Pourtois, E. Burgener, D. R. Faith, A. Joyce, T. Lamma, G. Kumar, P. L. Bollyky, P. R. Secor

This study deletes Pf prophages from P. aeruginosa isolates and examines their impact on quorum sensing, biofilm formation, and virulence traits.

bioRxiv · Nov 19, 2023 · PreprintMicrobiology

Inhibition of PQS signaling by the Pf bacteriophage protein PfsE enhances viral replication in Pseudomonas aeruginosa

C. M. Schwartzkopf, V. L. Taylor, M.-C. Groleau, D. R. Faith, A. K. Schmidt, T. L. Lamma, D. M. Brooks, E. Deziel, K. L. Maxwell, P. R. Secor

The paper identifies PfsE as a Pf phage protein that inhibits PQS quorum sensing and type IV pili extension, enhancing viral replication and protecting the host from competing phages.

bioRxiv · Aug 25, 2023Microbiology

Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission

A. L. Sapiro, B. M. Hayes, R. F. Volk, J. Y. Zhang, D. M. Brooks, C. Martyn, A. Radkov, Z. Zhao, M. Kinnersley, P. R. Secor, B. W. Zaro, S. Chou

This study maps transcriptome changes in Borrelia burgdorferi during tick-borne transmission by analyzing gene expression over four days in ticks.

bioRxiv · Nov 9, 2022 · PreprintMicrobiology

Tripartite interactions between filamentous Pf4 bacteriophage, Pseudomonas aeruginosa, and bacterivorous nematodes

C. M. Schwartzkopf, A. J. Robinson, M. Ellenbecker, D. R. Faith, D. M. Brooks, L. Lewerke, E. Voronina, A. A. Dandekar, P. R. Secor

This study shows that curing Pseudomonas aeruginosa of Pf4 phage infection increases virulence in C. elegans by enhancing PQS quorum sensing and pyocyanin production, but nematodes unable to detect bacterial pigments are more susceptible to the Pf4-cured strain.

bioRxiv · Oct 11, 2022Microbiology

Bacterial threat assessment of bacteriophage infection is mediated by intracellular polyamine accumulation and Gac/Rsm signaling

C. D. de Mattos, A. Nemudryi, D. Faith, D. C. Bublitz, L. Hammond, M. Kinnersley, C. M. Schwartzkopf, A. J. Robinson, A. Joyce, L. A. Michaels, R. Brzozowski, A. Coluccio, D. Xing, J. Uchiyama, L. K. Jennings, , P. R. Secor

This study shows that Pseudomonas aeruginosa uses intracellular polyamine accumulation and Gac/Rsm signaling to assess bacterial cell death and inhibit phage replication.

bioRxiv · Apr 1, 2022Microbiology

Modelling of filamentous phage-induced antibiotic tolerance of P.aeruginosa

M. T. van Rossem, S. Wilks, M. Kaczmarek, P. R. Secor, G. DAlessandro

The paper models how tactoids formed by filamentous Pf bacteriophage in Pseudomonas aeruginosa increase antibiotic diffusion times, leading to antibiotic tolerance.

bioRxiv · Dec 3, 2021 · PreprintMicrobiology

The depletion mechanism can actuate bacterial aggregation by self-produced exopolysaccharides and determine species distribution and composition in bacterial aggregates

P. R. Secor, L. A. Michaels, D. C. Bublitz, L. K. Jennings, P. K. Singh

This study shows depletion aggregation driven by P. aeruginosa exopolysaccharides influences bacterial species distribution and composition in mixed cultures.

bioRxiv · May 11, 2021Microbiology

Methods for Extraction and Detection of Bacteriophage DNA from the Sputum of Patients with Cystic Fibrosis

E. B. Burgener, P. R. Secor, M. C. Tracy, J. M. Sweere, E. M. Bik, C. E. Milla, P. Bollyky

This paper evaluates and optimizes methods for extracting bacteriophage DNA from CF patient sputum to improve detection of both bacteria and bacteriophage.

PHAGE: Therapy, Applications, and Research · Jun 16, 2020Peer-reviewedMicrobiology

Filamentous Bacteriophage Delay Healing of Pseudomonas-Infected Wounds

M. S. Bach, C. R. de Vries, A. Khosravi, J. M. Sweere, M. Popescu, A. Hargil, J. D. Van Belleghem, G. Kaber, Q. Chen, E. B. Burgener, D. Liu, Q.-L. Tran, T. Dharmaraj, M. Birukova, V. Sunkari, , P. L. Bollyky

This study shows filamentous bacteriophage delays wound healing in Pseudomonas aeruginosa infections by inhibiting keratinocyte migration, supported by a patient cohort study.

bioRxiv · Mar 10, 2020Microbiology