Author

A. M. Baschnagel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1

Frequent Co-Authors

A. Durmaz· 2 shared J. G. Scott· 2 shared L. Abel· 2 shared R. J. Kimple· 2 shared A. Cifci· 1 shared A. Karve· 1 shared C. A. Longhurst· 1 shared C. Longhurst· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

A. Durmaz

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4 papers

Recent·Most cited

GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors

D. Bhatacharya, R. Barille, D. K. Toukam, V. S. Gawali, L. Kallay, T. Ahmed, H. Brown, S. Rezvanian, A. Karve, P. B. Desai, M. Medvedovic, K. Wang, D. Ionascu, N. Harun, C. Wang, , S. Sengupta

This paper shows that activating GABA(A) receptors in lung cancer cells triggers autophagy via GABARAP-Nix interaction, enhancing radiation sensitivity and reducing toxicity in preclinical models.

bioRxiv · Nov 29, 2023Cancer Biology

MET Inhibitor Capmatinib Radiosensitizes MET Exon 14-Mutated and MET-Amplified Non-Small Cell Lung Cancer

S. Ramesh, A. Cifci, S. Javeri, R. Minne, C. A. Longhurst, K. P. Nickel, R. Kimple, A. M. Baschnagel

This study shows that capmatinib radiosensitizes MET exon 14-mutated and MET-amplified NSCLC cells and tumors, inhibiting DNA repair and reducing tumor growth.

bioRxiv · Oct 26, 2023Cancer Biology

Development and Characterization of Patient-Derived Xenografts from Non-Small Cell Lung Cancer Brain Metastases

A. M. Baschnagel, S. Kaushik, A. Durmaz, S. Goldstein, I. M. Ong, L. Abel, P. A. Clark, T. Leal, D. Buehler, G. Iyer, J. G. Scott, R. J. Kimple

This study establishes and characterizes patient-derived xenografts of NSCLC brain metastases, showing strong phenotypic and molecular correlation with original tumors and therapeutic response to targeted treatments.

bioRxiv · Jun 2, 2020Cancer Biology

Impact of immediate cryopreservation on the establishment of patient derived xenografts from head and neck cancer patients.

L. Abel, A. Durmaz, R. Hu, C. Longhurst, A. M. Baschnagel, D. L. Wheeler, J. G. Scott, R. J. Kimple

This study shows that fresh human cancer tissue can be cryopreserved and later implanted to establish PDXs without affecting growth rates or histologic parameters, enabling molecular profiling before implantation.

bioRxiv · Feb 3, 2020Cancer Biology