Author

R. J. Kimple

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

A. Durmaz· 2 shared A. M. Baschnagel· 2 shared G. Iyer· 2 shared I. M. Ong· 2 shared J. G. Scott· 2 shared L. Abel· 2 shared A. A. Gillette· 1 shared A. H. Yeung· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

A. Durmaz

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Author profile →

5 papers

Recent·Most cited

Targeted inhibition of BET proteins in HPV-16 associated head and neck squamous cell carcinoma reveals heterogeneous transcription response

A. Rao, Z. Ni, D. Suresh, C. Mohanty, A. Wang, D. Lee, K. Nickel, S. Varambally, R. J. Kimple, P. F. Lambert, C. Kendziorski, G. Iyer

This study shows BET inhibition reduces E6 and E7 expression in HPV-16 HNSCC, with variable effects on p53 and Rb, and induces G1 arrest and apoptosis.

bioRxiv · Oct 2, 2023 · PreprintCancer Biology

Integrating Subclonal Response Heterogeneity to Define Cancer Organoid Therapeutic Sensitivity

J. D. Kratz, S. Rehman, K. A. Johnson, A. A. Gillette, A. Sunil, P. F. Favreau, C. A. Pasch, D. Miller, L. C. Zarling, A. H. Yeung, L. Clipson, S. J. Anderson, A. K. DeZeeuw, C. M. Sprackling, K. K. Lemmon, , D. A. Deming

The paper evaluates individual patient-derived cancer organoids using optical metabolic imaging to predict therapeutic response and identify subclonal populations and resistance mechanisms.

bioRxiv · Oct 15, 2021 · PreprintCancer Biology

Development and Characterization of Patient-Derived Xenografts from Non-Small Cell Lung Cancer Brain Metastases

A. M. Baschnagel, S. Kaushik, A. Durmaz, S. Goldstein, I. M. Ong, L. Abel, P. A. Clark, T. Leal, D. Buehler, G. Iyer, J. G. Scott, R. J. Kimple

This study establishes and characterizes patient-derived xenografts of NSCLC brain metastases, showing strong phenotypic and molecular correlation with original tumors and therapeutic response to targeted treatments.

bioRxiv · Jun 2, 2020Cancer Biology

Impact of immediate cryopreservation on the establishment of patient derived xenografts from head and neck cancer patients.

L. Abel, A. Durmaz, R. Hu, C. Longhurst, A. M. Baschnagel, D. L. Wheeler, J. G. Scott, R. J. Kimple

This study shows that fresh human cancer tissue can be cryopreserved and later implanted to establish PDXs without affecting growth rates or histologic parameters, enabling molecular profiling before implantation.

bioRxiv · Feb 3, 2020Cancer Biology

High-throughput quantitative detection of basal autophagy and autophagic flux using image cytometry

G. Senthilkumar, J. H. Skiba, R. J. Kimple

This paper introduces a high-throughput, inexpensive, and objective method to quantify basal autophagy and autophagic flux using image cytometry and acridine orange staining.

bioRxiv · Jun 1, 2019Cell Biology