Author

A. M. Michie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Assay:bulk RNA-seq· 5 Research Focus:differential expression· 5 Organism:human· 4 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2

Frequent Co-Authors

J. Hay· 4 shared K. M. Dunn· 3 shared H. G. Jorgensen· 2 shared J. Cassels· 2 shared M. E. Massett· 2 shared N. Malik· 2 shared S. D. Patterson· 2 shared X. Huang· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersCancer Biology

J. Hay

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

MYC-NFATC2 axis maintains cell cycle and mitochondrial function in AML cells

S. D. Patterson, M. E. Massett, X. Huang, H. G. Jorgensen, A. M. Michie

This study identifies NFATC2 as a novel target of KDM4A in AML cells, showing its role in cell cycle progression and mitochondrial function through interactions with MYC and CCND1.

bioRxiv · Nov 15, 2023 · PreprintCancer Biology

IL-27 maintains cytotoxic Ly6C+ gamma delta T cells that arise from immature precursors

R. Wiesheu, S. C. Edwards, A. Hedley, M. Tosolini, M. G. F. Fares da Silva, N. Sumaria, Y. Optaczy, D. G. Hill, A. J. Hayes, J. Hay, A. Kilbey, A. M. Michie, G. Graham, A. Manoharan, C. Halsey, , S. B. Coffelt

The paper identifies immature and mature subsets of IFNγ-producing γδ T cells, showing IL-27 supports cytotoxic function in mature cells but not immature ones.

bioRxiv · Oct 26, 2023Immunology

PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signaling

J. Hay, A. Tarafdar, A. Holroyd, H. A. Moka, K. M. Dunn, A. Alshayeb, B. H. Lloyd, J. Cassels, N. Malik, A. F. Khan, I. Sou, J. Lees, H. N. Almuhanna, N. Kalakonda, J. R. Slupsky, A. M. Michie

This study shows PKCβ promotes CLL by enhancing BCR signaling and identifies SP1 as a regulator of PKCβ expression in leukemogenesis.

bioRxiv · Sep 4, 2022 · PreprintCancer Biology

Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells

H. Donnelly, E. Ross, Y. Xiao, R. Hermantara, A. F. J. M. A. Taqi, W. S. Doherty-Boyd, J. Cassels, P. M. Tsimbouri, K. M. Dunn, J. Hay, Z. A. Cheng, N. Jain, C. C. West, H. Wheadon, A. M. Michie, , M. J. Dalby

This study develops a bioengineered niche that maintains long-term haematopoietic stem cells by recreating physiological extracellular matrix organisation, supporting their survival and function without media supplementation.

bioRxiv · Jul 28, 2022 · PreprintBioengineering

mTORC1 activity is essential for disease progression in chronic lymphocytic leukemia

N. Malik, J. Hay, K. M. Dunn, R. Nakagawa, O. J. Sansom, A. M. Michie

This study shows that mTORC1 is essential for CLL progression in mice, with rapamycin effectively targeting eEF2 to inhibit proliferation and MCL1 expression.

bioRxiv · Apr 19, 2022 · PreprintCancer Biology

A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival

M. E. Massett, L. Monaghan, S. D. Patterson, N. Mannion, R. P. Bunschoten, A. Hoose, S. Marmiroli, R. M. Liskamp, H. G. Jorgensen, D. Vetrie, A. M. Michie, X. Huang

This study identifies KDM4A's role in AML by showing its regulation of an epigenomic network critical for cell survival and self-renewal, and highlights a gene signature for risk stratification.

bioRxiv · Oct 30, 2020Cancer Biology