Author

S. C. Edwards

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:flow cytometry· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

S. B. Coffelt· 4 shared A. Hedley· 3 shared A. Kilbey· 3 shared K. Blyth· 3 shared R. Wiesheu· 3 shared C. Miller· 2 shared J.-J. Fournie· 2 shared K. Kirschner· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersImmunology

S. B. Coffelt

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Author profile →

4 papers

Recent·Most cited

IL-27 maintains cytotoxic Ly6C+ gamma delta T cells that arise from immature precursors

R. Wiesheu, S. C. Edwards, A. Hedley, M. Tosolini, M. G. F. Fares da Silva, N. Sumaria, Y. Optaczy, D. G. Hill, A. J. Hayes, J. Hay, A. Kilbey, A. M. Michie, G. Graham, A. Manoharan, C. Halsey, , S. B. Coffelt

The paper identifies immature and mature subsets of IFNγ-producing γδ T cells, showing IL-27 supports cytotoxic function in mature cells but not immature ones.

bioRxiv · Oct 26, 2023Immunology

NKG2D signaling regulates IL-17A-producing γδT cells to promote cancer progression

S. Curio, S. C. Edwards, T. Suzuki, J. McGovern, C. Triulzi, N. Yoshida, G. Jonsson, T. Glauner, D. Rami, R. Purcell, S. B. Coffelt, N. Guerra

This study shows that NKG2D signaling promotes IL-17A-producing γδT cells, which drive cancer progression in intestinal tumors.

bioRxiv · Aug 26, 2021 · PreprintImmunology

Single-cell analysis uncovers differential regulation of lung γδ T cell subsets by the co-inhibitory molecules, PD-1 and TIM-3

S. C. Edwards, A. Hedley, W. H. M. Hoevenaar, T. Glauner, R. Wiesheu, A. Kilbey, R. Shaw, K. Boufea, N. Batada, K. Blyth, C. Miller, K. Kirschner, S. B. Coffelt

This study identifies differential regulation of lung γδ T cell subsets by PD-1 and TIM-3 using single-cell RNA sequencing and flow cytometry.

bioRxiv · Jul 4, 2021Immunology

Ly6C defines a subset of memory-like CD27+ γδ T cells with inducible cancer-killing function

R. Wiesheu, S. C. Edwards, A. Hedley, K. Kirschner, M. Tosolini, J.-J. Fournie, A. Kilbey, S.-J. Remak, C. Miller, K. Blyth, S. B. Coffelt

The paper identifies two subsets of CD27+ γδ T cells in mice, distinguished by Ly6C expression, with one subset showing memory-like properties and cancer-killing potential.

bioRxiv · Sep 8, 2020 · PreprintImmunology