Author

J. Rappaport

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Biochemistry· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 8 Organism:non-human primate· 7 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Research Focus:drug response / drug discovery· 4 Research Focus:cell-cell communication· 2 Assay:proteomics· 2

Frequent Co-Authors

R. V. Blair· 8 shared K. Russell-Lodrigue· 7 shared N. Golden· 7 shared N. J. Maness· 6 shared R. P. Bohm· 6 shared C. J. Roy· 5 shared L. A. Doyle-Meyers· 5 shared P. P. Aye· 5 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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8 shared papersImmunology

R. V. Blair

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection

A. Melton, L. A. Rowe, T. Penney, C. Krzykwa, K. Goff, S. E. Scheuermann, H. J. Melton, K. Williams, N. Golden, K. Moore Green, B. Smith, K. Russell-Lodrigue, J. P. Dufour, L. A. Doyle-Meyers, F. Schiro, , N. J. Maness

This study examines how SIV-induced immunodeficiency affects SARS-CoV-2 infection in macaques, finding that while immune responses are impaired, viral kinetics and evolution remain unchanged.

bioRxiv · Nov 15, 2023 · PreprintImmunology

Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Model of Long-COVID

C. S. Palmer, C. Perdios, M. Abdel-Mohsen, J. Mudd, P. Datta, N. Maness, G. Lehmicke, N. Golden, L. Hellmer, C. Coyne, K. Moore Green, C. Midkiff, K. Williams, R. Tiburcio, M. Fahlberg, , J. Rappaport

This study establishes a non-human primate model of metabolic PASC, identifies immune correlates of hyperglycemia, and shows vaccine-induced glycemic improvement.

bioRxiv · Sep 22, 2023 · PreprintImmunology

Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine

P. S. Arunachalam, Y. Feng, U. Ashraf, M. Hu, V. V. Edara, V. I. Zarnitsyna, P. P. Aye, N. Golden, K. W. M. Green, B. M. Threeton, N. J. Maness, B. J. Beddingfield, R. P. Bohm, J. Dufour, K. Russell-Lodrigue, , B. Pulendran

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

bioRxiv · Mar 18, 2022 · PreprintImmunology

The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease

A. Melton, L. A. Doyle-Meyers, R. V. Blair, C. Midkiff, H. J. Melton, K. Russell-Lodrigue, P. P. Aye, F. Schiro, M. Fahlberg, D. Szeltner, S. Spencer, B. J. Beddingfield, K. Goff, N. Golden, T. Penney, , N. J. Maness

This study shows that pigtail macaques infected with SARS-CoV-2 exhibit mild-to-moderate disease with specific immune and viral dynamics, making them a potential model for studying COVID-19.

bioRxiv · Aug 28, 2021Immunology

An Orally Available Cathepsin L Inhibitor Protects Lungs Against SARS-CoV-2-Induced Diffuse Alveolar Damage in African Green Monkeys

F. W. Frueh, D. C. Maneval, R. P. Bohm, J. P. Dufour, R. V. Blair, S. Simpson, K. Powell, P. P. Aye, N. A. Golden, C. J. ROY, S. Spencer, K. Russell-Lodrigue, K. S. Plante, J. A. Plante, J. H. McKerrow, J. Rappaport

This study shows that the orally available cathepsin L inhibitor K777 reduces SARS-CoV-2-induced lung damage in African green monkeys.

bioRxiv · Jul 20, 2021 · PreprintImmunology

Effective prophylaxis of COVID-19 in rhesus macaques using a combination of two parentally-administered SARS-CoV-2 neutralizing antibodies

B. J. Beddingfield, N. J. Maness, A. C. Fears, J. Rappaport, P. P. Aye, K. E. Russell-Lodrigue, L. A. Doyle-Meyers, R. V. Blair, A. M. Carias, R. L. Redondo, P. J. Madden, H. Gao, D. Montefiori, T. J. Hope, C. J. ROY

This study shows that a combination of two SARS-CoV-2 neutralizing antibodies prevents COVID-19 in rhesus macaques, with full protection at a higher dose and partial protection at lower doses.

bioRxiv · May 26, 2021Microbiology

Safety, immunogenicity and protection provided by unadjuvanted and adjuvanted formulations of recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in non-human primates

S. Pillet, P. S. Arunachalam, G. Andreani, N. Golden, J. Fontenot, P. Aye, K. Röltgen, G. Lehmick, C. Dube, P. Gobeil, S. Trepanier, N. Charland, M.-A. D'Aoust, K. Russell-Lodrigue, R. V. Blair, , N. Landry

This study evaluates the safety and immunogenicity of a plant-derived VLP vaccine against SARS-CoV-2 in non-human primates, finding that AS03 adjuvanted vaccine provides better protection and immune response.

bioRxiv · May 15, 2021Immunology

SARS-CoV-2 Beta Variant Substitutions Alter Spike Glycoprotein Receptor Binding Domain Structure and Stability

D. L. Moss, J. Rappaport

The paper examines how amino-acid substitutions in SARS-CoV-2 variants affect the structure, stability, and ACE2-binding ability of the spike glycoprotein receptor-binding domain.

bioRxiv · May 11, 2021Biochemistry

Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates

M. D. Fahlberg, R. V. Blair, L. A. Doyle-Meyers, C. C. Midkiff, G. Zenere, K. E. Russell-Lodrigue, C. J. Monjure, E. H. Haupt, T. P. Penney, G. Lehmicke, B. M. Threeton, N. Golden, P. K. Datta, C. J. Roy, R. P. Bohm, , M. Vaccari

This study examines immune events in non-human primates infected with SARS-CoV-2, identifying cellular correlates of disease severity and potential therapeutic targets.

bioRxiv · Jul 21, 2020Immunology

Acute Respiratory Distress and Cytokine Storm in Aged, SARS-CoV-2 Infected African Green Monkeys, but not in Rhesus Macaques

R. V. Blair, M. Vaccari, L. A. Doyle-Meyers, C. J. Roy, K. Russell-Lodrigue, M. Fahlberg, C. J. Monjure, B. Beddingfield, K. S. Plante, J. A. Plante, S. C. Weaver, X. Qin, C. C. Midkiff, G. Lehmicke, N. Golden, , J. Rappaport

This study compares SARS-CoV-2 infection in aged African green monkeys and rhesus macaques, finding ARDS and cytokine storms in AGMs but not RMs.

bioRxiv · Jun 18, 2020 · PreprintPathology