Cancer BiologybioRxivPreprint
Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASmut melanoma
B. Lipchick, A. N. Guterres, H.-Y. Chen…·J. Villanueva
This study identifies S6K2 as a vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma, showing its abrogation disrupts lipid homeostasis and triggers cell death.
DOI 10.1101/2021.04.07.438684