Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASmut melanoma
B. Lipchick, A. N. Guterres, H.-Y. Chen, D. M. Zundell, S. Del Aguila, P. I. Reyes-Uribe, S. Basu, X. Yin, A. V. Kossenkov, Y. Lu, G. B. Mills, Q. Liu, A. R. Goldman, M. E. Murphy, D. W. Speicher, J. Villanueva
This study identifies S6K2 as a vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma, showing its abrogation disrupts lipid homeostasis and triggers cell death.
bioRxiv · Apr 7, 2021 · PreprintCancer Biology