Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness
O. Eskiocak, S. Chowdhury, V. Shah, E. Nnuji-John, C. Chung, J. A. Boyer, A. S. Harris, J. Habel, M. Sadelain, S. Beyaz, C. Amor
This study shows that senolytic CAR T cells remove senescent cells in the aging gut, improving intestinal regeneration and immune function.
bioRxiv · Mar 19, 2024 · PreprintCell Biology