Author

A. P. Turnbull

Primary ORCID profile (0000-0001-6545-4108 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

A. P. TurnbulliD1 paper · The Francis Crick Institute

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:mouse· 1

Frequent Co-Authors

A. Pinto-Fernandez· 2 shared B. M. Kessler· 2 shared A. Behrens· 1 shared A. Damianou· 1 shared C. Da Costa· 1 shared C. Heride· 1 shared C. J. Dinsmore· 1 shared C. McKinnon· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. Pinto-Fernandez

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2 papers

Recent·Most cited

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

D. P. O'Brien, H. B. Jones, F. Guenther, E. J. Murphy, K. S. England, M. Anderson, P. Brennan, J. B. Davis, A. Pinto-Fernandez, A. P. Turnbull, B. M. Kessler

This study investigates how a benzosulfonamide compound inhibits USP30, a mitochondrial deubiquitylating enzyme, using biochemical and structural methods to reveal its binding mechanism and selectivity.

bioRxiv · Sep 13, 2022Biochemistry

USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma

E. J. Ruiz, A. Pinto-Fernandez, A. P. Turnbull, L. Lan, T. M. Charlton, H. C. Scott, A. Damianou, G. Vere, E. M. Riising, C. Da Costa, W. W. Krajewski, D. Guerin, J. Kearns, S. Ioannidis, M. Katz, , A. Behrens

This study shows that deleting or inhibiting USP28 reduces c-Myc levels and causes regression of lung squamous cell carcinoma in mice and human xenografts.

bioRxiv · Nov 17, 2020Cancer Biology