Author

A. Damianou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

B. M. Kessler· 5 shared A. Pinto-Fernandez· 4 shared C. S. Olie· 2 shared G. Vere· 2 shared H. C. Scott· 2 shared I. Vendrell· 2 shared N. Jones· 2 shared T. R. Hammonds· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersCancer Biology

B. M. Kessler

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Proximity proteomics reveals UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia

Z. Liang, A. Damianou, I. Vendrell, E. Jenkins, F. H. Lassen, S. J. Washer, G. Liu, G. Yi, H. Lou, F. Cao, X. Zheng, R. Fernandes, T. Dong, E. W. Tate, E. D. Daniel, B. M. Kessler

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

bioRxiv · Oct 9, 2023 · PreprintBiochemistry

Sex-specific deubiquitylation drives immune-related neurodegeneration in Drosophila

J. Xia, A. Pinto-Fernandez, A. Damianou, J. Lee, B. M. Kessler, I. Davis, P. R. Elliott, P. Ligoxygakis

This study shows that sex-specific deubiquitylation by Trabid in Drosophila influences neurodegeneration linked to immune responses and protein accumulation.

bioRxiv · Dec 9, 2022 · PreprintImmunology

USP18 is an essential regulator of muscle cell differentiation and maturation

C. S. Olie, A. Pinto-Fernandez, A. Damianou, I. Vendrell, H. Mei, B. den Hamer, E. van der Wal, J. C. de Greef, E. Aronica, V. Raz, B. M. Kessler

This study identifies USP18 as a critical regulator of muscle cell differentiation and maturation, independent of its role in the ISG response.

bioRxiv · Apr 1, 2022 · PreprintCell Biology

USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma

E. J. Ruiz, A. Pinto-Fernandez, A. P. Turnbull, L. Lan, T. M. Charlton, H. C. Scott, A. Damianou, G. Vere, E. M. Riising, C. Da Costa, W. W. Krajewski, D. Guerin, J. Kearns, S. Ioannidis, M. Katz, , A. Behrens

This study shows that deleting or inhibiting USP28 reduces c-Myc levels and causes regression of lung squamous cell carcinoma in mice and human xenografts.

bioRxiv · Nov 17, 2020Cancer Biology

Essential roles for deubiquitination in Leishmania life cycle progression

A. Damianou, R. J. Burge, C. Catta-Preta, V. Geoghegan, Y. R. Nievas, K. Newling, E. Brown, R. Burchmore, B. Rodenko, J. C. Mottram

This study identifies essential deubiquitinating enzymes (DUBs) in Leishmania life cycle progression and demonstrates their critical role in differentiation and intracellular survival.

PLOS Pathogens · Jun 16, 2020Peer-reviewedMicrobiology

Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity

A. Pinto-Fernandez, M. Salio, T. Partridge, J. Chen, G. Vere, H. Greenwood, C. S. Olie, A. Damianou, H. C. Scott, H. J. Pegg, A. Chiarenza, L. Diaz-Saez, P. Smith, C. Gonzalez-Lopez, B. Patel, , B. M. Kessler

This study identifies novel ISGylation targets regulated by USP18, showing its role in enhancing tumour cell antigenicity and reducing radiosensitivity in CML cells.

bioRxiv · Mar 31, 2020 · PreprintCancer Biology