Author

A. Pahl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 3 Approach:deep learning· 2 Assay:imaging· 2 Assay:CRISPR screen· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

H. Waldmann· 3 shared S. Sievers· 3 shared S. Ziegler· 3 shared J. Warmers· 2 shared S. Koska· 2 shared S. Rezaei Adariani· 2 shared A. B. Abarientos· 1 shared A. Burhop· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

H. Waldmann

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4 papers

Recent·Most cited

Detection of a Mitochondrial Stress Phenotype using the Cell Painting Assay

S. Rezaei Adariani, D. Agne, S. Koska, A. Burhop, J. Warmers, P. Janning, M. Metz, A. Pahl, S. Sievers, H. Waldmann, S. Ziegler

The paper shows that the Cell Painting assay can detect mitochondrial stress and predict mitochondrial toxicity in small molecules.

bioRxiv · Nov 8, 2023 · PreprintCell Biology

Illuminating Dark Chemical Matter using the Cell Painting Assay

A. Pahl, J. Liu, S. Patil, S. Rezaei Adariani, B. Scholermann, J. Bonowski, S. Koska, S. Sievers, J. Warmers, S. Ziegler, H. Waldmann

The paper uses the Cell Painting Assay to identify bioactive compounds in dark chemical matter, revealing modulators of microtubules, DNA synthesis, and pyrimidine biosynthesis.

bioRxiv · May 31, 2023Cell Biology

Morphological Subprofile Analysis for Bioactivity Annotation of Small Molecules

A. Pahl, B. Schoelermann, M. Rusch, M. Dow, C. Hedberg, A. Nelson, S. Sievers, H. Waldmann, S. Ziegler

This paper introduces subprofile analysis to predict the mode of action of small molecules using morphological profiling data, enabling rapid bioactivity annotation without requiring extensive reference compounds.

bioRxiv · Aug 15, 2022Cell Biology

CRISPR-based screens uncover determinants of immunotherapy response in Multiple Myeloma

P. Ramkumar, A. B. Abarientos, R. Tian, M. Seyler, J. T. Leong, M. Chen, P. Choudhry, T. Hechler, N. Shah, S. W. Wong, T. G. Martin, J. L. Wolf, K. T. Roybal, A. Pahl, J. Taunton, , M. Kampmann

This study uses CRISPR screens to identify mechanisms increasing BCMA expression and enhancing anti-myeloma efficacy of BCMA-targeted therapies in multiple myeloma.

bioRxiv · Apr 14, 2020Cancer Biology