S. Sievers

Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3

The paper identifies iDegs, which enhance IDO1 degradation via the native CRL2KLHDC3 pathway, reducing kynurenine formation and offering new therapeutic potential for cancer.

Discovery of the sEH Inhibitor Epoxykynin as Potent Kynurenine Pathway Modulator

The paper identifies epoxykynin as a potent sEH inhibitor that modulates the kynurenine pathway, offering new opportunities to address cancer-induced immune tolerance.

Detection of a Mitochondrial Stress Phenotype using the Cell Painting Assay

The paper shows that the Cell Painting assay can detect mitochondrial stress and predict mitochondrial toxicity in small molecules.

Illuminating Dark Chemical Matter using the Cell Painting Assay

The paper uses the Cell Painting Assay to identify bioactive compounds in dark chemical matter, revealing modulators of microtubules, DNA synthesis, and pyrimidine biosynthesis.

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP

This study identifies orpinolide as a compound that disrupts cholesterol transport in leukemia by targeting OSBP, revealing a therapeutic strategy for leukemic dependencies.

Morphological Subprofile Analysis for Bioactivity Annotation of Small Molecules

This paper introduces subprofile analysis to predict the mode of action of small molecules using morphological profiling data, enabling rapid bioactivity annotation without requiring extensive reference compounds.

Work horse strain Clostridioides difficile 630Δerm is oblivious to its anaerobic lifestyle

The study shows that the C. difficile strain 630Δerm has a mutation in PerR that causes oxidative stress response under anaerobic conditions, challenging its use as a model strain.