Author

A. R. Farghli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

P. Sethupathy· 3 shared M. Nukaya· 2 shared T. Gujral· 2 shared A. Benito-Martin· 1 shared A. J. Shumway· 1 shared A. Yen· 1 shared C. A. Bradfield· 1 shared C. Cafferty· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

P. Sethupathy

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3 papers

Recent·Most cited

DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma

R. K. Ma, P.-Y. Tsai, A. R. Farghli, A. J. Shumway, M. Kanke, J. D. Gordan, T. Gujral, K. Vakili, M. Nukaya, L. Noetzli, S. Ronnekleiv-Kelly, W. Broom, J. Barrow, P. Sethupathy

This paper identifies LINC00473 as a downstream mediator of DNAJB1-PRKACA fusion in fibrolamellar carcinoma, showing it promotes tumor growth and alters mitochondrial function.

bioRxiv · Jun 2, 2023Cancer Biology

CDK7 is a Novel Therapeutic Vulnerability in Fibrolamellar Carcinoma

M. Nukaya, C. Cafferty, K. Zahed, I. Yun, D. P. Al-Adra, N. A. Kazim, A. R. Farghli, M. Chan, J. D. Kratz, M. E. Berres, A. Yen, T. Gujral, P. Sethupathy, C. A. Bradfield, S. M. Ronnekleiv-Kelly

This study identifies CDK7 as a therapeutic target in fibrolamellar carcinoma by showing its activation in FLC cells and efficacy of CDK7 inhibitors in patient-derived models.

bioRxiv · Apr 22, 2023 · PreprintCancer Biology

Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism

S. Liu, A. Benito-Martin, F. A. P. Vatter, S. Z. Hanif, C. Liu, P. Bhardwaj, P. Sethupathy, A. R. Farghli, P. Piloco, P. Paik, M. Mushannen, D. M. Otterburn, L. Cohen, R. Bareja, J. Krumsiek, , K. A. Brown

This study shows that extracellular vesicles from obese women's breast adipose tissue promote mitochondrial metabolism and proliferation in ER+ breast cancer cells.

bioRxiv · Feb 8, 2023 · PreprintCancer Biology