Author

K. A. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Biochemistry· 3

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 4 Assay:proteomics· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

D. S. Roberts· 3 shared J. A. Spector· 3 shared P. Bhardwaj· 3 shared Y. Ge· 3 shared C. Liu· 2 shared D. D. Giri· 2 shared E. J. Larson· 2 shared J. A. Melby· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

D. S. Roberts

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization

N. Ben-Chetrit, X. Niu, J. Sotelo, A. D. Swett, V. K. Rajasekhar, M. S. Jiao, C. M. Stewart, P. Bhardwaj, S. Kottapalli, S. Ganesan, P.-L. Loyher, C. Potenski, A. Hannuna, K. A. Brown, N. M. Iyengar, , D. A. Landau

This study identifies spatial localization as a key determinant of macrophage heterogeneity and self-renewal in breast cancer, with implications for therapeutic strategies.

bioRxiv · Oct 24, 2023 · PreprintCancer Biology

Comprehensive Characterization of Endogenous Phospholamban Proteoforms Enabled by Photocleavable Surfactant and Top-down Proteomics

H. T. Rogers, D. S. Roberts, E. J. Larson, J. A. Melby, K. J. Rossler, A. V. Carr, K. A. Brown, Y. Ge

This paper develops a top-down proteomics method to characterize endogenous phospholamban proteoforms in cardiac tissue, revealing site-specific PTMs.

bioRxiv · Apr 12, 2023Biochemistry

Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism

S. Liu, A. Benito-Martin, F. A. P. Vatter, S. Z. Hanif, C. Liu, P. Bhardwaj, P. Sethupathy, A. R. Farghli, P. Piloco, P. Paik, M. Mushannen, D. M. Otterburn, L. Cohen, R. Bareja, J. Krumsiek, , K. A. Brown

This study shows that extracellular vesicles from obese women's breast adipose tissue promote mitochondrial metabolism and proliferation in ER+ breast cancer cells.

bioRxiv · Feb 8, 2023 · PreprintCancer Biology

High Sensitivity Top-down Proteomics Captures Single Muscle Cell Heterogeneity in Large Proteoforms

J. A. Melby, K. A. Brown, Z. R. Gregorich, D. S. Roberts, E. A. Chapman, L. E. Ehlers, Z. Gao, E. J. Larson, Y. Jin, J. Lopez, J. Hartung, Y. Zhu, D. Wang, W. Guo, G. M. Diffee, Y. Ge

This study develops a sensitive top-down proteomics method to analyze large proteoforms in single muscle cells, revealing heterogeneity and linking it to muscle fiber types.

bioRxiv · Dec 29, 2022 · PreprintBiochemistry

Obesity promotes breast epithelium DNA damage in BRCA mutation carriers

P. Bhardwaj, N. M. Iyengar, H. Zahid, K. M. Carter, D. J. Byun, M.-H. Choi, Q. Sun, O. Savenkov, C. Louka, C. Liu, P. Piloco, M. Acosta, R. Bareja, O. Elemento, M. Foronda, , K. A. Brown

The paper shows that obesity increases DNA damage in breast epithelium of BRCA mutation carriers and suggests targeting estrogen or metabolic dysfunction may reduce breast cancer risk.

bioRxiv · Jul 29, 2022 · PreprintCancer Biology

One-Pot Exosome Proteomics Enabled by a Photocleavable Surfactant

K. M. Buck, D. S. Roberts, T. J. Aballo, D. R. Inman, S. Jin, S. M. Ponik, K. A. Brown, Y. Ge

This paper introduces a one-pot exosome proteomics method using a photocleavable surfactant, enabling rapid and effective exosomal lysis, protein extraction, and digestion, with high reproducibility and coverage.

bioRxiv · Mar 18, 2022Biochemistry

Unacylated ghrelin and AZP531 suppress the 3D growth of breast cancers

C. C. Au, J. B. Furness, K. Britt, S. Oshchepkova, H. Ladumor, K. Y. Soo, B. Callaghan, C. Gerard, G. Inghirami, V. Mittal, Y. Wang, X.-Y. Huang, J. A. Spector, E. Andreopoulou, P. Zumbo, , K. A. Brown

This study shows unacylated ghrelin and its analog AZP531 inhibit breast cancer growth in 3D cultures and xenografts by suppressing MAPK signaling and inducing apoptosis.

bioRxiv · Jan 22, 2020 · PreprintCancer Biology

No effect of administration of unacylated ghrelin on subcutaneous PC3 xenograft growth in a Rag1-/- mouse model of metabolic dysfunction

M. L. Maugham, L. K. Chopin, I. Seim, P. B. Thomas, G. J. Crisp, E. T. Shah, A. C. Herington, K. A. Brown, L. S. Gregory, C. C. Nelson, P. L. Jeffery

This study investigates the effect of unacylated ghrelin on PC3 xenograft growth in Rag1-/- mice with metabolic dysfunction, finding no effect on tumor growth but improved glucose tolerance.

bioRxiv · May 22, 2018Cancer Biology