Author

P. T. Edlefsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Assay:flow cytometry· 2 Organism:mouse· 2 Organism:non-human primate· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. B. Ventura· 1 shared A. Bhusari· 1 shared A. E. Golfinos· 1 shared A. J. Balgeman· 1 shared A. J. Weaver· 1 shared A. Kaur· 1 shared A. Khandhar· 1 shared A. L. Ellis-Connell· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. B. Ventura

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Author profile →

6 papers

Recent·Most cited

A non-invasive method to sample immune cells in the lower female genital tract using menstrual discs

M. Q. Peters, E. Domenjo-Vila, M. Carlson, B. Armistead, P. T. Edlefsen, M. Gasper, S. Dabee, C. Whidbey, H. B. Jaspan, M. Prlic, W. E. Harrington

This paper develops a non-invasive method using menstrual discs to sample immune cells from the female genital tract, demonstrating consistent T cell populations across days within individuals.

bioRxiv · Nov 16, 2023 · PreprintImmunology

Assessing vaccine-mediated protection in an ultra-low dose Mycobacterium tuberculosis murine model

C. R. Plumlee, H. W. Barrett, D. E. Shao, K. A. Lien, L. M. Cross, S. B. Cohen, P. T. Edlefsen, K. B. Urdahl

This study evaluates BCG vaccine efficacy using an ultra-low dose Mtb murine model, showing enhanced protection compared to conventional models.

bioRxiv · Mar 22, 2023 · PreprintMicrobiology

A replicon RNA vaccine induces durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

M. A. O'Connor, D. W. Hawman, K. Meade-White, S. Leventhal, W. Song, S. Randall, J. Archer, T. B. Lewis, B. Brown, N. Iwayama, C. Ahrens, W. Garrison, S. Wangari, K. A. Guerriero, P. Hanley, , J. H. Erasmus

This study shows a replicon RNA vaccine provides durable protection against SARS-CoV-2 in nonhuman primates even after neutralizing antibodies decline.

bioRxiv · Aug 8, 2022 · PreprintImmunology

Transient T cell expansion, activation, and proliferation in therapeutically vaccinated SIV+ macaques treated with N-803

O. E. Harwood, A. J. Balgeman, A. J. Weaver, A. L. Ellis-Connell, A. M. Weiler, K. N. Erickson, L. M. Matschke, A. E. Golfinos, V. Vezys, P. J. Skinner, J. T. Safrit, P. T. Edlefsen, M. R. Reynolds, T. C. Friedrich, S. L. O'Connor

This study shows that therapeutic vaccination with a heterologous prime-boost regimen followed by N-803 treatment enhances CD8+ T cell responses in SIV-infected macaques.

bioRxiv · Jul 8, 2022 · PreprintImmunology

Co-immunization with pre-erythrocytic antigens alongside circumsporozoite protein can enhance sterile protection against Plasmodium sporozoite infection.

V. Vigdorovich, H. Patel, A. Watson, A. Raappana, L. Reynolds, W. Selman, S. Beeman, P. T. Edlefsen, S. H. I. Kappe, D. N. Sather

This paper shows that combining multiple pre-erythrocytic antigens with CSP enhances sterile protection against Plasmodium sporozoite infection in a mouse model.

bioRxiv · Jun 17, 2022 · PreprintImmunology

In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome

H. Taher, E. Mahyari, C. Kreklywich, L. S. Uebelhoer, M. R. McArdle, M. J. Moström, A. Bhusari, M. Nekorchuk, T. Whitmer, E. A. Scheef, L. M. Sprehe, D. Roberts, C. M. Hughes, K. A. Jackson, A. N. Selseth, , D. Malouli

This paper constructs a full-length rhesus cytomegalovirus (RhCMV) by repairing mutations in the 68-1 strain and shows it replicates more effectively in vivo compared to the passaged strain.

bioRxiv · Jun 2, 2020Microbiology