Author

N. Hertoghs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

J. Carnes· 2 shared J. D. Aitchison· 2 shared K. D. Stuart· 2 shared K. V. Schwedhelm· 2 shared M. J. McElrath· 2 shared M. L. Neal· 2 shared S. C. De Rosa· 2 shared S. H. I. Kappe· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

J. Carnes

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge

D. A. Oyong, F. J. Duffy, M. L. Neal, Y. Du, J. Carnes, K. V. Schwedhelm, N. Hertoghs, S.-H. Jun, H. Miller, J. D. Aitchison, S. C. De Rosa, E. W. Newell, M. J. McElrath, S. M. McDermott, K. D. Stuart

The paper identifies distinct immune responses associated with vaccination status and protection outcomes after malaria challenge using transcriptome and cellular profiling.

bioRxiv · Dec 9, 2022 · PreprintImmunology

Plasmodium GPI-Anchored Micronemal Antigen is essential for parasite transmission through the mosquito host

C. Jennison, J. M. Gibson, N. Hertoghs, D. A. Dankwa, S. Kumar, B. A. Abatiyow, M. Naung, N. K. Minkah, K. E. Swearingen, R. L. Moritz, A. E. Barry, S. H. I. Kappe, A. M. Vaughan

This study shows that GAMA is essential for Plasmodium sporozoite motility, egress from oocysts, and invasion of the vertebrate host, with distinct roles in each process.

bioRxiv · Feb 24, 2022 · PreprintMicrobiology

Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and enhance protection of anti-CSP monoclonal antibodies

B. K. Wilder, V. Vigdorovich, S. Carbonetti, N. Minkah, N. Hertoghs, A. Raappana, H. Cardamone, B. G. Oliver, O. Trakhimets, S. Kumar, N. Dambrauskas, S. A. Arredondo, N. Camargo, S. H. I. Kappe, D. N. Sather

This study shows that anti-TRAP/SSP2 monoclonal antibodies inhibit sporozoite infection and enhance protection from CSP-based antibodies, suggesting a multivalent vaccine strategy could improve malaria vaccines.

bioRxiv · Oct 15, 2021 · PreprintMicrobiology

Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity

Y. Du, N. Hertoghs, J. Carnes, S. M. McDermott, M. L. Neal, K. V. Schwedhelm, M. J. McElrath, S. C. De Rosa, J. D. Aitchison, K. D. Stuart

The paper analyzes immune responses to malaria vaccination and finds that excessive early inflammation correlates with impaired immunity.

bioRxiv · Jul 28, 2021Immunology