Author

A. Sakai

Primary ORCID profile (0000-0003-3120-0104 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

A. SakaiiD1 paper · Brain Research Institute, Niigata University

Biology Disciplines

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Evolutionary Biology· 1 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:Arabidopsis· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Assay:electrophysiology· 1

Frequent Co-Authors

C. Furusawa· 1 shared H. Hirai· 1 shared H. Kaminaka· 1 shared H. Kotani· 1 shared H. Yamagata· 1 shared I. Okamura· 1 shared J. Iwasawa· 1 shared K. Naito· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperEvolutionary Biology

C. Furusawa

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3 papers

Recent·Most cited

Induced systemic resistance by the root colonization of Trichoderma atroviride is independent from the chitin-mediated signaling pathway in Arabidopsis

A. Sakai, H. Yamagata, K. Naito, T. Tominaga, S. Ifuku, H. Kaminaka

This study shows that Trichoderma atroviride induces systemic resistance in Arabidopsis independently of the chitin signaling pathway, but shares similar transcriptional responses with chitin.

bioRxiv · May 3, 2024 · PreprintPlant Biology

Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain

A. Sakai, T. Yasui, M. Watanave, R. Tatsumi, Y. Yamamoto, W. Takano, Y. Tani, I. Okamura, H. Hirai, S. Takeda, S. Takeda

This study identifies novel GPR85 inverse-agonists with IC50 values around 1 µM and shows they modulate potassium channel opening in cerebellar Purkinje cells.

bioRxiv · Sep 18, 2021Pharmacology & Toxicology

High-throughput laboratory evolution and evolutionary constraints in Escherichia coli

T. Maeda, J. Iwasawa, H. Kotani, N. Sakata, M. Kawada, T. Horinouchi, A. Sakai, K. Tanabe, C. Furusawa

This study uses high-throughput lab evolution of E. coli to identify evolutionary constraints and trade-offs in antibiotic resistance.

bioRxiv · Feb 19, 2020Evolutionary Biology