S. Takeda

Exon 44 skipping in Duchenne muscular dystrophy: NS-089/NCNP-02, a dual-targeting antisense oligonucleotide

This study develops NS-089/NCNP-02, a dual-targeting ASO for exon 44 skipping in DMD, showing effective in vitro and in vivo exon skipping and dystrophin expression.

A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage

The paper develops a 384-well CometChip platform for high-throughput DNA damage analysis and identifies 3-methyladenine as an enhancer of etoposide-induced DNA damage.

Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain

This study identifies novel GPR85 inverse-agonists with IC50 values around 1 µM and shows they modulate potassium channel opening in cerebellar Purkinje cells.

Crocosphaera as a major consumer of fixed nitrogen despite its capability of nitrogen fixation

This study shows Crocosphaera efficiently consumes combined nitrogen sources and maintains high growth rates even when nitrogen is limited, highlighting its ecological importance.

Therapeutic targeting of SLC6A8 creatine transporter inhibits KRAS mutant and wildtype colon cancer and modulates human creatine levels

RGX-202 inhibits CRC growth by targeting SLC6A8 creatine transporter, reduces creatine and ATP levels, and shows efficacy in multiple tumor models and human trials.

Isolation and characterization of a novel phage SaGU1 that infects Staphylococcus aureus clinical isolates from patients with atopic dermatitis

This study isolates and characterizes a novel phage SaGU1 that infects S. aureus clinical isolates from atopic dermatitis patients, showing it is safe and effective for phage therapy.

Estrogen induces mammary ductal dysplasia.

This study shows estrogen can cause mammary ductal dysplasia in a mouse model and demonstrates that isoflavones can inhibit this effect.

Spatial chromosome folding and active transcription drive DNA fragility and formation of oncogenic MLL translocations

The paper shows that transcription and spatial chromosome folding increase DNA fragility, leading to oncogenic translocations in leukemia.

Clearance of senescent decidual cells by uterine natural killer cells drives endometrial remodeling during the window of implantation