Author

A. Santos-Lopez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:whole-genome sequencing· 3 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C. W. Marshall· 3 shared V. S. Cooper· 3 shared A. San Millan· 2 shared C. Costas· 2 shared J. DelaFuente· 2 shared J. Rodriguez-Beltran· 2 shared L. Toribio-Celestino· 2 shared M. Hernandez-Garcia· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMicrobiology

C. W. Marshall

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Plasmid-encoded insertion sequences promote rapid adaptation in clinical enterobacteria

J. Sastre-Dominguez, J. DelaFuente, L. Toribio-Celestino, C. Herencias, P. Herrador-Gomez, C. Costas, M. Hernandez-Garcia, R. Canton, J. Rodriguez-Beltran, A. Santos-Lopez, A. San Millan

This study shows plasmid-encoded insertion sequences (IS1) enhance bacterial adaptation by increasing gene inactivation rates in clinical enterobacteria.

bioRxiv · Mar 1, 2024Microbiology

Within-patient evolution of plasmid-mediated antimicrobial resistance

J. DelaFuente, L. Toribio-Celestino, A. Santos-Lopez, R. Leon-Sampedro, A. Aida Alonso-del Valle, C. Costas, M. Hernandez-Garcia, L. Cui, J. Rodriguez-Beltran, D. Bikard, R. Canton, A. San Millan

This study tracks the evolution of plasmid-mediated antimicrobial resistance in hospitalized patients, revealing trade-offs between resistance levels and bacterial fitness.

bioRxiv · May 31, 2022Evolutionary Biology

The roles of history, chance, and natural selection in the evolution of antibiotic resistance

A. Santos-Lopez, C. W. Marshall, A. L. Welp, C. B. Turner, J. Rasero, V. S. Cooper

This study quantifies how history, chance, and selection influence the evolution of antibiotic resistance in Acinetobacter baumannii through controlled experiments.

bioRxiv · Jul 22, 2020Evolutionary Biology

Parallel evolution of tobramycin resistance across species and environments

M. R. Scribner, A. Santos-Lopez, C. W. Marshall, C. Deitrick, V. S. Cooper

This study identifies parallel mutations in fusA1 and ptsP across two bacterial species under tobramycin selection, showing predictable resistance mechanisms despite environmental and genetic differences.

bioRxiv · Sep 6, 2019Microbiology

Evolutionary pathways to antibiotic resistance are dependent upon environmental structure and bacterial lifestyle

A. Santos-Lopez, C. W. Marshall, M. R. Scribner, D. Snyder, V. S. Cooper

This study shows that biofilm lifestyle in Acinetobacter baumannii leads to different genetic pathways and fitness trade-offs in antibiotic resistance evolution compared to planktonic growth.

bioRxiv · Apr 12, 2019Microbiology