R. Leon-Sampedro

Clinical Antibiotic-Resistance Plasmids Have Small Effects on Biofilm Formation and Population Growth in Escherichia coli in vitro

This study tests how clinical antibiotic-resistance plasmids affect biofilm formation and growth in Escherichia coli, finding small or no effects in most cases.

Within-patient evolution of plasmid-mediated antimicrobial resistance

This study tracks the evolution of plasmid-mediated antimicrobial resistance in hospitalized patients, revealing trade-offs between resistance levels and bacterial fitness.

The distribution of plasmid fitness effects explains plasmid persistence in bacterial communities

The study determines the distribution of fitness effects for plasmid pOXA-48 in gut bacteria, showing quasi-neutral effects and beneficial effects in some isolates, and links plasmid persistence to bacterial diversity and phylogeny.

Collateral Sensitivity Associated with Antibiotic Resistance Plasmids

This study investigates collateral sensitivity associated with antibiotic resistance plasmids, showing its conservation in clinical isolates and potential for selective elimination of plasmid-carrying bacteria.

Dissemination routes of the carbapenem resistance plasmid pOXA-48 in a hospital setting

This study characterizes the dissemination routes of the carbapenem resistance plasmid pOXA-48 in a hospital setting using mechanistic models and genomic data.

Carbapenemases on the move: it’s good to be on ICE

This study identifies ICEs in Pseudomonas aeruginosa that carry carbapenemase-encoding genes, highlighting their role in antibiotic resistance spread.