J. DelaFuente

Plasmid-encoded insertion sequences promote rapid adaptation in clinical enterobacteria

This study shows plasmid-encoded insertion sequences (IS1) enhance bacterial adaptation by increasing gene inactivation rates in clinical enterobacteria.

Community context influences the conjugation efficiency of E. coli

The paper investigates how polymicrobial communities affect conjugation rates of uropathogenic E. coli in artificial urine medium, finding that Gram-positive enterococci enhance conjugation rates.

β-lactamase expression induces collateral sensitivity in Escherichia coli

This study shows that β-lactamase expression in E. coli induces collateral sensitivity to colistin and azithromycin, suggesting a therapeutic strategy to counter mobile AMR.

The distribution of fitness effects of plasmid pOXA-48 in clinical enterobacteria

This study investigates the fitness effects of the plasmid pOXA-48 in clinical enterobacteria using CRISPR-Cas9 to cure plasmids, revealing mostly neutral effects with rare fitness costs or benefits.

Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria

The paper investigates how antimicrobial resistance levels and conjugation permissiveness influence plasmid distribution in clinical enterobacteria, showing that specific bacterial clones stabilize plasmid spread.

Within-patient evolution of plasmid-mediated antimicrobial resistance

This study tracks the evolution of plasmid-mediated antimicrobial resistance in hospitalized patients, revealing trade-offs between resistance levels and bacterial fitness.

Fitness effects of CTX-M-15-encoding IncF plasmids on their native Escherichia coli ST131 H30Rx hosts

This study examines the fitness effects of CTX-M-15-encoding IncF plasmids in E. coli ST131 H30Rx hosts, finding moderate fitness costs in some strains but not others.

The distribution of plasmid fitness effects explains plasmid persistence in bacterial communities

The study determines the distribution of fitness effects for plasmid pOXA-48 in gut bacteria, showing quasi-neutral effects and beneficial effects in some isolates, and links plasmid persistence to bacterial diversity and phylogeny.

Dissemination routes of the carbapenem resistance plasmid pOXA-48 in a hospital setting

This study characterizes the dissemination routes of the carbapenem resistance plasmid pOXA-48 in a hospital setting using mechanistic models and genomic data.