Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917
I. Gelfat, Y. Aqeel, J. M. Tremblay, J. Jaskiewicz, A. Shrestha, J. N. Lee, S. Hu, X. Qian, L. Magoun, A. Sheoran, D. Bedenice, C. Giem, A. Manjula-Basavanna, M. S. Osbourne, S. Tzipori, , N. S. Joshi
The paper develops VHH-based therapeutics displayed on probiotic E. coli Nissle 1917 to target enteric pathogens, showing they can bind and neutralize virulence factors.
bioRxiv · Jun 18, 2021Microbiology