X. Qian

A spatially resolved genomic molecular atlas of human white-matter microstructure

This paper maps genetic, proteomic, and metabolomic effects along human white-matter tracts using UK Biobank data, revealing localized associations with neurodegenerative and psychiatric traits.

Connectome-based spatial statistics enabling large-scale population analyses of human connectome across cohorts

This paper introduces CBSS, a framework for analyzing structural connectomes across multiple cohorts, showing its reliability and utility in cross-cohort diffusion MRI studies.

Mapping rare protein-coding variants on multi-organ imaging traits

The paper identifies rare protein-coding variants associated with multi-organ MRI traits using exome-wide association analysis in the UK Biobank.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

Using split protein reassembly strategy to control PLD enzymatic activity

This study uses split protein reassembly and optogenetic techniques to control PLD enzymatic activity by modulating domain interactions.

Harnessing Gradients for Self-Assembly of Peptide-Based Nanocapsules: A Pathway to Advanced Drug Delivery Systems

The paper describes the spontaneous formation of peptide-based nanocapsules through a solvent gradient-driven self-assembly process, offering a new approach for drug delivery systems.

Rapid Prototyping of Thermoplastic Microfluidic 3D Cell Culture Devices by Creating Regional Hydrophilicity Discrepancy

This paper develops a method to rapidly prototype thermoplastic microfluidic devices for 3D cell culture by creating regional hydrophilicity discrepancies, enabling dynamic cell culture and drug screening.

Reciprocal polarization imaging of complex media.

This paper introduces reciprocal polarization imaging to quantify anisotropic properties of complex media using backscattering Mueller matrices, demonstrating its effectiveness in various applications.

Single shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad and durable systemic and mucosal immune responses

This study evaluates a SARS-CoV-2 vaccine candidate that targets dendritic cells, showing durable systemic and mucosal immune responses against multiple variants.

Transcriptionally defined morphological subtypes of pancreatic ductal adenocarcinoma

The paper identifies five transcriptional subtypes of PDAC cells with distinct morphological patterns and confirms their prognostic significance using bulk RNA-sequencing datasets.

Mapping the allosteric effects that define functional activity of SARS-CoV-2 specific antibodies

This study identifies site-specific allosteric effects in SARS-CoV-2 Spike protein induced by different neutralizing antibodies, revealing dynamic features that distinguish weak from strong neutralizers.

Diverse pathogens activate the host RIDD pathway to subvert BLOS1-directed immune defense

This study shows that pathogens like Brucella and coronavirus MHV exploit the RIDD pathway to degrade BLOS1, impairing lysosomal trafficking and enhancing their intracellular survival.

A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal MRSA populations

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917

The paper develops VHH-based therapeutics displayed on probiotic E. coli Nissle 1917 to target enteric pathogens, showing they can bind and neutralize virulence factors.

Retinal organoids derived from rhesus macaque iPSCs undergo accelerated differentiation compared to human stem cells

This study compares retinal organoid differentiation speed between rhesus macaque and human stem cells, finding NHP-derived organoids develop faster.

Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to dictate full host defense against tospovirus infection

This study shows that the tomato NLR Sw-5b acts in both cytoplasm and nucleus to provide full resistance against tospovirus by blocking different infection stages.

SARS-CoV-2 S protein ACE2 interaction reveals novel allosteric targets

The paper investigates how ACE2 binding to SARS-CoV-2 Spike protein allosterically affects proteolysis at distal cleavage sites and highlights potential therapeutic targets.

Machine Learning Maps Research Needs in COVID-19 Literature

The paper uses machine learning to analyze COVID-19 literature and identifies research gaps and hotspots through metadata and text analysis.

Numerical simulation for behind armor blunt trauma of human torso under non-penetrating ballistic impact

This study simulates behind armor blunt trauma in a human torso model under ballistic impact to evaluate how buffer layers reduce injury severity.

Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma

The paper uses in situ sequencing to analyze immune transcript localization in tuberculosis granulomas, revealing time-dependent immune landscape changes and spatial transcriptomic patterns.

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.