N. S. Joshi

Microbially Driven Reversible Actuation and Color Changing Materials

This paper demonstrates an engineered living material driven by E. coli that reversibly swells and de-swells a pH-responsive hydrogel, accompanied by a color change.

The PD-1 checkpoint receptor maintains tolerance of self-reactive CD8 T cell in skin

The paper shows that PD-1+ CD8 T cells in healthy skin remain tolerant to self-antigens and prevent tissue damage through PD-L1 upregulation on myeloid cells.

Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917

The paper develops VHH-based therapeutics displayed on probiotic E. coli Nissle 1917 to target enteric pathogens, showing they can bind and neutralize virulence factors.

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

The paper identifies a reservoir of stem-like CD8 T cells in tumor-draining lymph nodes that sustain anti-tumor immunity by maintaining TCF1 expression and resisting terminal differentiation.

Neoantigen-driven B cell and CD4+ T follicular helper cell collaboration promotes robust anti-tumor CD8+ T cell responses

This study shows that TFH-B cell interactions driven by neoantigens enhance anti-tumor CD8+ T cell responses in lung adenocarcinoma.

NINJA: an inducible genetic model for creating neoantigens in vivo

The paper develops a genetic model called NINJA to create inducible neoantigens in mice, enabling controlled T cell responses without central tolerance.

Probiotic Associated Therapeutic Curli Hybrids (PATCH)

This study genetically engineers Escherichia coli to produce an anti-inflammatory matrix of curli nanofibers fused with trefoil factors, showing protective effects against colitis in mice.