Author

I. Gelfat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

N. S. Joshi· 2 shared A. M. Duraj-Thatte· 1 shared A. Manjula-Basavanna· 1 shared A. Sheoran· 1 shared A. Shrestha· 1 shared C. B. Shoemaker· 1 shared C. Giem· 1 shared D. B. Chou· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

N. S. Joshi

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917

I. Gelfat, Y. Aqeel, J. M. Tremblay, J. Jaskiewicz, A. Shrestha, J. N. Lee, S. Hu, X. Qian, L. Magoun, A. Sheoran, D. Bedenice, C. Giem, A. Manjula-Basavanna, M. S. Osbourne, S. Tzipori, , N. S. Joshi

The paper develops VHH-based therapeutics displayed on probiotic E. coli Nissle 1917 to target enteric pathogens, showing they can bind and neutralize virulence factors.

bioRxiv · Jun 18, 2021Microbiology

Probiotic Associated Therapeutic Curli Hybrids (PATCH)

P. Praveschotinunt, A. M. Duraj-Thatte, I. Gelfat, F. Bahl, D. B. Chou, N. S. Joshi

This study genetically engineers Escherichia coli to produce an anti-inflammatory matrix of curli nanofibers fused with trefoil factors, showing protective effects against colitis in mice.

bioRxiv · Nov 7, 2018 · PreprintBioengineering