Author

S. R. Denmeade

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

A. Gupta· 1 shared A. M. De Marzo· 1 shared A. Shetty· 1 shared A. Vaghasia· 1 shared B. Ozbek· 1 shared C. J. Paller· 1 shared C. V. Dang· 1 shared D. Topiwala· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Gupta

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2 papers

Recent·Most cited

CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor.

R. Kumar, J. Mendonca, A. Shetty, Y. Yang, O. Owoyemi, L. C. Wilson, K. Boyapati, D. Topiwala, N. Thomas, H. Nguyen, J. Luo, C. J. Paller, S. R. Denmeade, M. A. Carducci, S. K. Kachhap

This study shows CRM1 regulates androgen receptor stability and DNA repair in prostate cancer, suggesting combination therapy with CRM1 and DNA repair inhibitors could be effective.

bioRxiv · Feb 13, 2024Cancer Biology

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

J. Chen, Q. Zheng, J. L. Hicks, L. Trabzonlu, B. Ozbek, T. Jones, A. Vaghasia, T. C. Larman, R. Wang, M. C. Markowski, S. R. Denmeade, K. J. Pienta, R. H. Hruban, E. S. Antonarakis, A. Gupta, , A. M. De Marzo

The paper develops a method to spatially quantify mitochondrial DNA copy number in cancer tissues and finds increased mtDNAcn in prostate cancer progression, linked to MYC activity.

bioRxiv · Feb 20, 2023Cancer Biology