Author

A. Silale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Approach:microscopy & imaging analysis· 5 Assay:cryo-EM· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:protein folding & dynamics· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:structural biology· 2

Frequent Co-Authors

A. Basle· 5 shared B. van den Berg· 5 shared M. Trost· 2 shared S. Khalid· 2 shared Y. Zhu· 2 shared A. Gajbhiye· 1 shared A. Kjaer· 1 shared A. M. Frey· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersMicrobiology

A. Basle

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural basis of iron piracy by human gut Bacteroides

A. Silale, Y. L. Soo, H. Mark, R. N. Motz, A. Basle, E. M. Nolan, B. van den Berg

This study reveals the structural mechanism by which Bacteroides thetaiotaomicron steals iron-bound siderophores from pathogens using the XusAB complex.

bioRxiv · Apr 15, 2024Microbiology

An ancestral dual function of OmpM as outer membrane tether and nutrient uptake channel in diderm Firmicutes

A. Silale, Y. Zhu, J. Witwinowski, R. E. Smith, K. E. Newman, S. P. Bhamidimarri, A. Basle, S. Khalid, C. BELOIN, S. Gribaldo, B. van den Berg

This study identifies OmpM as a dual-function protein in diderm Firmicutes that tethers the outer membrane to peptidoglycan and facilitates nutrient uptake.

bioRxiv · Aug 14, 2023Biochemistry

BtuB TonB-dependent transporters and BtuG surface lipoproteins form stable complexes for vitamin B12 uptake in gut Bacteroides.

J. Abellon-Ruiz, K. Jana, A. Silale, A. M. Frey, A. Basle, M. Trost, U. Kleinekathofer, B. van den Berg

This study identifies stable complexes between BtuB transporters and BtuG lipoproteins in Bacteroides thetaiotaomicron for vitamin B12 uptake via cryoEM, X-ray crystallography, and MD simulations.

bioRxiv · Nov 17, 2022Microbiology

Outer membrane utilisomes mediate oligosaccharide uptake in gut Bacteroidetes

J. B. White, A. Silale, M. C. Feasey, T. Heunis, Y. Zhu, H. Zheng, A. Gajbhiye, S. Firbank, A. Basle, M. Trost, D. N. Bolam, N. A. Ranson, B. van den Berg

The paper identifies utilisomes as stable glycan-utilising complexes in Bacteroides thetaiotaomicron, revealing their structure and mechanism of substrate capture via cryo-EM.

bioRxiv · Aug 15, 2022Microbiology

Structural basis for host recognition and superinfection exclusion by bacteriophage T5

B. van den Berg, A. Silale, A. Basle, S. L. Mader, S. Khalid

This study reveals the structural basis of host recognition and superinfection exclusion by bacteriophage T5 through cryo-EM and crystal structures of its receptor and SE proteins.

bioRxiv · Jun 28, 2022Microbiology

Structure of a proton-powered molecular motor that drives protein transport and gliding motility

R. Hennell-James, J. Deme, A. Kjaer, F. Alcock, A. Silale, F. Lauber, B. Berks, S. M. Lea

This study determines the structure of a proton-driven motor in Bacteroidetes bacteria and identifies key residues involved in its function.

bioRxiv · May 11, 2020 · PreprintBiochemistry