Author

N. Bhardwaj

AstraZeneca (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cancer Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 7 Research Focus:cell type annotation· 6 Assay:bulk RNA-seq· 4 Research Focus:drug response / drug discovery· 4 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3

Frequent Co-Authors

A. Horowitz· 2 shared A. M. Farkas· 2 shared A. Solovyov· 2 shared A. Tocheva· 2 shared B. Greenbaum· 2 shared B. Lee· 2 shared C. Bieber· 2 shared J. Daza· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

A. Horowitz

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The HLA-E/NKG2A axis identifies a therapeutic vulnerability in BCG-unresponsive bladder cancer

Bérengère Salomé, Haocheng Yu, Daniel L Ranti, Ying‐Chih Wang, C. Bieber, Pierre‐Etienne Gabriel, Igor Duquesne, Trine Strandgaard, B. Hug, Sean Houghton, Hiranmayi Ravichandran, Elliot Merritt, S. Bang, A. Demetriou, Z. Li, , Amir Horowitz

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

bioRxiv · Sep 2, 2024 · PreprintCancer Biology

Natural Killer Cell Dysfunction In Human Bladder Cancer Is Caused By Tissue-Specific Suppression of SLAMF6 Signaling

A. M. Farkas, D. Youssef, M. A. Tran, S. Balan, J. H. Newman, F. Audenet, H. Anastos, L. G. Velazquez, A. Peros, A. Ananthanarayanan, J. Daza, E. Gonzalez-Gugel, K. Sadanala, J. Theorell, M. D. Galsky, , N. Bhardwaj

This study identifies SLAMF6 signaling suppression in bladder cancer tumor microenvironment as a cause of NK cell dysfunction, showing restoration of function under normoxic conditions.

bioRxiv · Apr 30, 2024 · PreprintImmunology

Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer

D. Ranti, Y.-S. Wang, J. Daza, C. Bieber, B. Salome, E. Merritt, J.-A. Cavallo, E. Hegewisch-Solloa, E. M. Mace, A. M. Farkas, S. Schroff, B. Lee, M. Tran, T. Strandgaard, S. V. Lindskrog, , A. Horowitz

The paper identifies elevated HLA-E and NKG2A as markers of resistance to BCG immunotherapy in NMIBC, linked to immune escape mechanisms.

bioRxiv · Mar 6, 2022 · PreprintImmunology

Cyclic constrained immunoreactive peptides from crucial P. falciparum proteins: potential implications in malaria diagnostics

K. VASHISHT, S. SRIVASTAVA, V. KUMARI, R. DAS, S. SHARMA, N. BHARDWAJ, A. R. ANVIKAR, T. S. KIM, B. K. NA, H. J. SHIN, K. C. PANDEY

The paper identifies three cyclic constrained peptides from P. falciparum proteins that show immunoreactivity and diagnostic potential in field-collected samples.

bioRxiv · Oct 11, 2021Biochemistry

Perturb-map enables CRISPR genomics with spatial resolution and identifies regulators of tumor immune composition

M. Dhainaut, S. A. Rose, G. Akturk, A. Wroblewska, E. Sook Park, S. R. Nielsen, M. Buckup, V. Roudko, L. Pia, J. Le Berichel, A. Bektesevic, B. H. Lee, A. Baccarini, N. Bhardwaj, A. H. Rahman, , B. D. Brown

Perturb-map enables spatial CRISPR screening in tumors, identifying genes that regulate immune composition by mapping gene knockouts and their effects on the tumor microenvironment.

bioRxiv · Jul 13, 2021 · PreprintImmunology

Y-RNAs Lead an Endogenous Program of RIG-I Agonism Mobilized upon RNA Virus Infection and Targeted by HIV

N. Vabret, V. Najburg, A. Solovyov, P. Sulc, S. Balan, G. Beauclair, M. Chazal, H. Varet, R. Legendre, O. Sismeiro, R. Sanchez David, C. McClain, R. Gopal, L. Chauveau, O. Schwartz, , A. Komarova

This study identifies Y-RNAs as endogenous RIG-I ligands that are targeted by HIV through DUSP11 downregulation, enhancing their immunogenicity and triggering antiviral responses.

bioRxiv · Sep 18, 2019Immunology

Widespread immunogenic poly-epitope frameshift mutations in microsatellite unstable tumors

V. Roudko, C. Cimen Bozkus, T. Orfanelli, S. V. Blank, B. Greenbaum, N. Bhardwaj

The paper identifies immunogenic poly-epitope frameshift mutations in MSI-H tumors and validates their potential for off-the-shelf cancer vaccines.

bioRxiv · Jun 12, 2019 · PreprintCancer Biology

P2X antagonists inhibit HIV-1 productive infection and inflammatory cytokines IL-10 and IL-1β in a human tonsil explant model

A. Y. Soare, N. Durham, R. Gopal, B. Tweel, K. W. Hoffman, J. A. Brown, M. O'Brien, N. Bhardwaj, J. K. Lim, B. K. Chen, T. H. Swartz

bioRxiv · Jul 10, 2018Immunology

Global Cancer Transcriptome Quantifies Repeat Element Polarization Between Immunotherapy Responsive and T cell Suppressive Classes

A. Solovyov, N. Vabret, K. S. Arora, A. Snyder, S. A. Funt, D. F. Bajorin, J. E. Rosenberg, N. Bhardwaj, D. T. Ting, B. D. Greenbaum

The paper quantifies repeat element polarization in cancer transcriptomes to identify biomarkers for immunotherapy response and tumor microenvironment immunosuppression.

bioRxiv · Jun 4, 2017Cancer Biology