Author

E. S. Manolakos

Northeastern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. V. Manatakis· 3 shared K. Karalis· 3 shared C. D. Hinojosa· 2 shared G. A. Hamilton· 2 shared I. Pediaditakis· 2 shared K. R. Kodella· 2 shared L. L. Rubin· 2 shared A. Apostolou· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBioengineering

D. V. Manatakis

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Microengineered Brain-Chip to Model Neuroinflammation in Humans

I. Pediaditakis, K. R. Kodella, D. V. Manatakis, C. Y. Le, S. Barthakur, A. Sorets, A. Gravanis, L. Ewart, L. L. Rubin, E. S. Manolakos, C. D. Hinojosa, K. Karalis

The paper presents a human Brain-Chip that models neuroinflammation by recapitulating brain cell interactions and BBB function, showing improved complexity and clinical relevance compared to existing models.

bioRxiv · Mar 11, 2022Bioengineering

A Micro-engineered Human Colon Intestine-Chip Platform to Study Leaky Barrier

A. Apostolou, R. Panchakshari, A. Banerjee, D. V. Manatakis, M. D. Paraskevopoulou, R. Luc, G. Abu Ali, A. Dimitriou, C. Lucchesi, G. Kulkarni, T. I. Maulana, B. Bleck, E. S. Manolakos, G. A. Hamilton, C. Giallourakis, K. Karalis

This paper introduces a Colon Intestine-Chip platform to study leaky gut by combining organoids and Organ-on-Chip technologies, showing its response to inflammatory cytokines and IL-22.

bioRxiv · Aug 28, 2020 · PreprintBioengineering

Modeling Alpha-Synuclein Pathology in a Human Brain-Chip to Assess Blood-Brain Barrier Disruption in Parkinson's Disease

I. Pediaditakis, K. R. Kodella, D. V. Manatakis, C. D. Hinojosa, E. S. Manolakos, L. L. Rubin, G. A. Hamilton, K. Karalis

The paper develops a human Brain-Chip model of Parkinson's disease to study blood-brain barrier disruption and synucleinopathy mechanisms.

bioRxiv · Jul 22, 2020Bioengineering

Machine learning methods to reverse engineer dynamic gene regulatory networks governing cell state transitions

Panagiοtis Tsakanikas, Dimitris V. Manatakis, E. S. Manolakos

This paper introduces a machine learning method to analyze single-cell gene expression data and reconstruct dynamic gene regulatory networks during cell state transitions, with application to hematopoiesis.

bioRxiv · Feb 13, 2018 · PreprintBioinformatics