G. Elias

SPLICER: A Highly Efficient Base Editing Toolbox That Enables In Vivo Therapeutic Exon Skipping

SPLICER improves exon skipping by editing both splice acceptor and donor sites, reducing aberrant splicing and enabling therapeutic applications in Alzheimer's disease.

Deep profiling of antigen-specific B cells from different pathogens identifies novel compartments in the IgG memory B cell and antibody-secreting cell lineages

The paper identifies novel stages in IgG memory B cell and antibody-secreting cell differentiation by analyzing antigen-specific B cells from different pathogens using high-dimensional flow cytometry.

Modeling Antigen-Specific T Cell Dynamics Following Hepatitis B Vaccination indicates differences between conventional and regulatory T cell dynamics

This study models T cell dynamics post-Hepatitis B vaccination, revealing differences between conventional and regulatory T cells and their relationship to antibody responses and seropositivity.

Integrated Drivers of Basal and Acute Immunity in Diverse Human Populations

The paper examines factors influencing immunity across diverse populations, finding ancestry and age significantly affect immune responses and disease severity.

Single-cell analysis reveals dynamics of human B cell differentiation and identifies novel B and antibody-secreting cell intermediates

The paper uses single-cell RNA sequencing to study human B cell differentiation, identifying novel intermediates and a germinal-center-like population in vitro.

Preexisting memory CD4 T cells in nÏave individuals confer robust immunity upon hepatitis B vaccination

The paper shows preexisting memory CD4 T cells in unvaccinated individuals correlate with stronger hepatitis B vaccine responses and predicts immune outcomes using TCR sequencing and machine learning.