Author

A. Toghani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Plant Biology· 4

Signature Assays, Organisms & Methods

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Organism:plant (other)· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C.-H. Wu· 4 shared H. Pai· 3 shared J. Kourelis· 3 shared L. Derevnina· 3 shared S. Kamoun· 3 shared A. Harant· 2 shared A. Maqbool· 2 shared D. M. Lawson· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPlant Biology

C.-H. Wu

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4 papers

Recent·Most cited

Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome

M. Selvaraj, A. Toghani, H. Pai, Y. Sugihara, J. Kourelis, E. L. H. Yuen, T. Ibrahim, H. Zhao, R. Xie, A. Maqbool, J. C. De la Concepcion, M. J. Banfield, L. Derevnina, B. Petre, D. M. Lawson, , M. P. Contreras

This study shows how the helper NLR NRC2 converts from a homodimer to a higher-order oligomer upon activation by the sensor NLR Rx, revealing the molecular mechanism of plant immune activation.

bioRxiv · Dec 17, 2023Plant Biology

A root-specific NLR network confers resistance to plant parasitic nematodes

D. Luedke, T. Sakai, J. Kourelis, A. Toghani, H. Adachi, A. Posbeyikian, R. Frijters, H. Pai, A. Harant, K. Ernst, M. Ganal, A. Verhage, C.-H. Wu, S. Kamoun

The paper identifies a root-specific NLR gene cluster in tomato that confers resistance to nematodes and evolved from an ancient NRC network.

bioRxiv · Dec 14, 2023 · PreprintPlant Biology

Functional divergence shaped the network architecture of plant immune receptors

C.-Y. Huang, Y.-S. Huang, Y. Sugihara, H.-Y. Wang, L.-T. Huang, J. C. Lopez-Agudelo, Y.-F. Chen, K.-Y. Lin, B.-J. Chiang, A. Toghani, J. Kourelis, L. Derevnina, C.-H. Wu

The paper shows how functional divergence in NRC3 variants shapes the genetic architecture of the NLR network in solanaceous plants, leading to subfunctionalization and increased immune system complexity.

bioRxiv · Dec 12, 2023 · PreprintPlant Biology

Resurrection of plant disease resistance proteins via helper NLR bioengineering

M. P. Contreras, H. Pai, M. Selvaraj, A. Toghani, D. M. Lawson, Y. Tumtas, C. Duggan, E. L. H. Yuen, C. E. M. Stevenson, A. Harant, A. Maqbool, C.-H. Wu, T. O. Bozkurt, S. Kamoun, L. Derevnina

A helper NLR is mutated to evade inhibition by a parasite effector, restoring disease resistance gene activity.

bioRxiv · Dec 11, 2022Plant Biology