L. Derevnina

The origin, deployment, and evolution of a plant-parasitic nematode effectorome

This study identifies and characterizes the effectorome of the plant-parasitic nematode Heterodera schachtii, revealing 659 effector gene loci and providing insights into their origin, deployment, and evolution.

Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome

This study shows how the helper NLR NRC2 converts from a homodimer to a higher-order oligomer upon activation by the sensor NLR Rx, revealing the molecular mechanism of plant immune activation.

Functional divergence shaped the network architecture of plant immune receptors

The paper shows how functional divergence in NRC3 variants shapes the genetic architecture of the NLR network in solanaceous plants, leading to subfunctionalization and increased immune system complexity.

NRC immune receptor networks show diversified hierarchical genetic architecture across plant lineages

The paper investigates the evolution of NRC immune receptor networks across plant lineages, finding significant expansion and complexity in lamiids compared to Ericales and campanulids.

Resurrection of plant disease resistance proteins via helper NLR bioengineering

A helper NLR is mutated to evade inhibition by a parasite effector, restoring disease resistance gene activity.

Effector-dependent activation and oligomerization of NRC helper NLRs by Rpi-amr3 and Rpi-amr1

This study shows that sensor NLRs Rpi-amr3 and Rpi-amr1 activate the helper NLR NRC2 to form a resistosome in response to Phytophthora effectors.

Sensor NLR immune proteins activate oligomerization of their NRC helper

The paper shows that activation of plant NLRs Rx and Bs2 leads to oligomerization of the helper NLR NRC2, suggesting a distinct activation model compared to mammalian paired NLRs.

The helper NLR immune protein NRC3 mediates the hypersensitive cell death caused by the cell-surface receptor Cf-4

The paper identifies NRC3 as an NLR protein required for hypersensitive cell death triggered by the PRR Cf-4 in response to the fungal effector Avr4.

Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network

The paper identifies effectors from plant pathogens that specifically target subsets of NRC immune receptor proteins, revealing convergent strategies to counteract redundant nodes in the NLR network.

Intra-strain elicitation and suppression of plant immunity by Ralstonia solanacearum type-III effectors in Nicotiana benthamiana

This study investigates how Ralstonia solanacearum uses effector proteins to elicit and suppress plant immunity in Nicotiana benthamiana.

An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species

The paper identifies a conserved N-terminal motif in plant NLR immune receptors and shows its functional conservation across species.

Lessons in effector and NLR biology of plant-microbe systems

The paper examines three effectors from the rice blast fungus and their corresponding rice NLR immune receptors to highlight general concepts of plant-microbe interactions and identify 12 lessons in effector and NLR biology.