Y. Sugihara

Impact of rice GENERAL REGULATORY FACTOR14h (GF14h) on low-temperature seed germination and its application to breeding

This paper identifies GF14h as the causal gene for low-temperature seed germination in rice and demonstrates its utility in breeding for direct seeding in cold climates.

Multiple horizontal mini-chromosome transfers drive genome evolution of clonal blast fungus lineages

The paper identifies horizontal mini-chromosome transfers in clonal blast fungus lineages, showing genetic exchange between host-associated isolates.

Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome

This study shows how the helper NLR NRC2 converts from a homodimer to a higher-order oligomer upon activation by the sensor NLR Rx, revealing the molecular mechanism of plant immune activation.

Functional divergence shaped the network architecture of plant immune receptors

The paper shows how functional divergence in NRC3 variants shapes the genetic architecture of the NLR network in solanaceous plants, leading to subfunctionalization and increased immune system complexity.

Histopathology-assisted proteogenomics provides foundations for stratification of melanoma metastases

This study integrates histopathology and proteogenomic data from melanoma metastases to identify subtypes and risk factors, offering a basis for personalized treatment strategies.

Proteogenomic Characterization Reveals Therapeutic Opportunities Related to Mitochondrial Function in Melanoma

This study uses proteomics to analyze mitochondrial function in melanoma samples, finding dysregulation linked to patient survival and treatment responses, and proposes therapeutic strategies targeting mitochondrial pathways.

Disentangling the complex gene interaction networks between rice and the blast fungus identifies a new pathogen effector

Whole genome sequencing of a wild yam species Dioscorea tokoro reveals a genomic region associated with sex

The paper reports the whole genome sequence of Dioscorea tokoro and identifies a genomic region associated with sex determination.

Apoplastic CBM1-interacting proteins bind conserved carbohydrate binding module 1 motifs in fungal hydrolases to counter pathogen invasion

The paper identifies OsCBMIP, a rice protein that binds to fungal CBM1 domains in xylanases, inhibiting their activity and enhancing rice defense against M. oryzae.

A genetically linked pair of NLR immune receptors show contrasting patterns of evolution

This paper studies the evolution of a rice NLR gene pair, showing that the sensor NLR undergoes dynamic domain integration under balancing selection, while the helper NLR remains functionally conserved under purifying selection.

Proteogenomics Reveals how Metastatic Melanoma Modulates the Immune System to Allow Immune Evasion

This paper analyzes proteogenomic data from melanoma patients to show how metastatic melanoma alters metabolism and immune responses to evade immune detection.

Genome analyses reveal the hybrid origin of the staple food crop white Guinea yam

This study reveals the hybrid origin of white Guinea yam through genomic analysis, showing it arose from crosses between D. praehensilis and D. abyssinica with significant introgression around the SWEETIE gene.