Author

A.-L. Castell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:rat· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Organism:human· 1

Frequent Co-Authors

J. Ghislain· 3 shared V. Poitout· 3 shared A. Vivoli· 2 shared A. Filali-Mouhim· 1 shared C. Des Rosiers· 1 shared C. Goubault· 1 shared C. Tremblay· 1 shared D. Dal Soglio· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

J. Ghislain

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Beta-cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood

A.-L. Castell, M. Ethier, G. Fergusson, C. Tremblay, C. Goubault, M. Baltz, D. Dal Soglio, J. Ghislain, V. Poitout

This study shows that puberty increases beta-cell proliferation via GH/serotonin signaling, and metabolic stress during puberty affects glucose homeostasis in adulthood.

bioRxiv · Apr 6, 2022Physiology

Single-cell RNA sequencing reveals a role for reactive oxygen species and peroxiredoxins in fatty-acid-induced rat β-cell proliferation

A. Vivoli, J. Ghislain, A. Filali-Mouhim, Z. E. Angeles, A.-L. Castell, R. Sladek, V. Poitout

This study uses single-cell RNA sequencing to show that oleate induces β-cell proliferation via ROS and peroxiredoxin signaling in rat islets, while palmitate does not.

bioRxiv · Dec 22, 2021Cell Biology

Very Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation

A.-L. Castell, A. Vivoli, T. S. Tippetts, I. Robillard Frayne, V. S. Moulle, M. Ruiz, J. Ghislain, C. Des Rosiers, W. L. Holland, S. A. Summers, V. Poitout

This study shows that oleate induces β-cell proliferation in rats via unsaturated very long-chain sphingolipids, mediated by ACBP and ELOVL1.

bioRxiv · Jul 16, 2021Cell Biology