J. Ghislain

Beta-cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood

This study shows that puberty increases beta-cell proliferation via GH/serotonin signaling, and metabolic stress during puberty affects glucose homeostasis in adulthood.

Single-cell RNA sequencing reveals a role for reactive oxygen species and peroxiredoxins in fatty-acid-induced rat β-cell proliferation

This study uses single-cell RNA sequencing to show that oleate induces β-cell proliferation via ROS and peroxiredoxin signaling in rat islets, while palmitate does not.

Very Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation

This study shows that oleate induces β-cell proliferation in rats via unsaturated very long-chain sphingolipids, mediated by ACBP and ELOVL1.

Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans

The paper investigates beta-cell mitogen efficacy in human islets, finding that harmine and HB-EGF stimulate beta-cell proliferation, while glucose effects vary by assay and donor.

Combined deletion of free fatty-acid receptors 1 and 4 minimally impacts glucose homeostasis in mice

This study shows that deleting both FFAR1 and FFAR4 in mice only slightly affects glucose homeostasis, with minor changes in fasting glucose and glucose tolerance.

Free-fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice

This study shows that GPR120 activation in delta cells inhibits somatostatin release, thereby enhancing insulin and glucagon secretion in mice.

HB-EGF Signaling is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats

This study shows HB-EGF signaling is essential for glucose-induced β-cell proliferation in rats, mediated through EGFR and ChREBP pathways.