Author

V. Poitout

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 5 Research Focus:differential expression· 4 Organism:rat· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3

Frequent Co-Authors

J. Ghislain· 7 shared C. Tremblay· 4 shared A. Vivoli· 3 shared A.-L. Castell· 3 shared G. Fergusson· 3 shared H. Maachi· 3 shared M. Ethier· 3 shared A. Guillaume· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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7 shared papersCell Biology

J. Ghislain

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Vitamin K-dependent carboxylation regulates calcium flux and adaptation to metabolic stress in β-cells

J. Lacombe, K. Guo, J. Bonneau, D. Faubert, F. Gioanni, A. Vivoli, S. M. Muir, S. Hezzaz, V. Poitout, M. Ferron

This study shows that vitamin K-dependent gamma-carboxylation in beta-cells regulates calcium flux and adaptation to metabolic stress by modulating ERGP function.

bioRxiv · May 13, 2022 · PreprintCell Biology

Beta-cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood

A.-L. Castell, M. Ethier, G. Fergusson, C. Tremblay, C. Goubault, M. Baltz, D. Dal Soglio, J. Ghislain, V. Poitout

This study shows that puberty increases beta-cell proliferation via GH/serotonin signaling, and metabolic stress during puberty affects glucose homeostasis in adulthood.

bioRxiv · Apr 6, 2022Physiology

Single-cell RNA sequencing reveals a role for reactive oxygen species and peroxiredoxins in fatty-acid-induced rat β-cell proliferation

A. Vivoli, J. Ghislain, A. Filali-Mouhim, Z. E. Angeles, A.-L. Castell, R. Sladek, V. Poitout

This study uses single-cell RNA sequencing to show that oleate induces β-cell proliferation via ROS and peroxiredoxin signaling in rat islets, while palmitate does not.

bioRxiv · Dec 22, 2021Cell Biology

Very Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation

A.-L. Castell, A. Vivoli, T. S. Tippetts, I. Robillard Frayne, V. S. Moulle, M. Ruiz, J. Ghislain, C. Des Rosiers, W. L. Holland, S. A. Summers, V. Poitout

This study shows that oleate induces β-cell proliferation in rats via unsaturated very long-chain sphingolipids, mediated by ACBP and ELOVL1.

bioRxiv · Jul 16, 2021Cell Biology

Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans

H. Maachi, J. Ghislain, C. Tremblay, V. Poitout

The paper investigates beta-cell mitogen efficacy in human islets, finding that harmine and HB-EGF stimulate beta-cell proliferation, while glucose effects vary by assay and donor.

bioRxiv · Oct 28, 2020Cell Biology

Combined deletion of free fatty-acid receptors 1 and 4 minimally impacts glucose homeostasis in mice

M. L. Croze, A. Guillaume, M. Ethier, G. Fergusson, C. Tremblay, S. A. Campbell, H. Maachi, J. Ghislain, V. Poitout

This study shows that deleting both FFAR1 and FFAR4 in mice only slightly affects glucose homeostasis, with minor changes in fasting glucose and glucose tolerance.

bioRxiv · Aug 4, 2020Physiology

Free-fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice

M. L. Croze, M. Flisher, A. Guillaume, C. Tremblay, G. M. Noguchi, S. Granziera, K. Vivot, V. C. Castillo, S. A. Campbell, J. Ghislain, M. O. Huising, V. Poitout

This study shows that GPR120 activation in delta cells inhibits somatostatin release, thereby enhancing insulin and glucagon secretion in mice.

bioRxiv · Jul 17, 2020Cell Biology

HB-EGF Signaling is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats

H. Maachi, G. Fergusson, M. Ethier, G. N. Brill, L. S. Katz, L. B. Honig, M. R. Metukuri, D. K. Scott, J. Ghislain, V. Poitout

This study shows HB-EGF signaling is essential for glucose-induced β-cell proliferation in rats, mediated through EGFR and ChREBP pathways.

bioRxiv · Dec 3, 2019Cell Biology