Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense
Adam S. Krebs, Tomi Lazarov, Anthony Reynolds, Kimberly A. Dill‐McFarland, Abigail Xie, James M. Bean, Muxue Du, Olivier Levy, John A. Buglino, Aaron Zhong, Anna‐Lena Neehus, Stéphanie Boisson‐Dupuis, Jean‐Laurent Casanova, Elouise E. Kroon, Marlo Möller, , Michael S. Glickman
This study investigates itaconate's role in human macrophages, showing distinct effects in alveolar-like and M-CSF-derived macrophages during M. tuberculosis infection.
bioRxiv · Jul 23, 2025 · PreprintImmunology