Cysteine depletion triggers adipose tissue thermogenesis and weight-loss.
Aileen H. Lee, Lucie Orliaguet, Yun‐Hee Youm, Rae Maeda, Tamara Dlugos, Yuanjiu Lei, Daniel Coman, Irina Shchukina, Prabhakar Sairam Andhey, Steven R. Smith, Éric Ravussin, Krisztián Stadler, Bandy Chen, Maxim N. Artyomov, Fahmeed Hyder, , Vishwa Deep Dixit
This study shows that cysteine depletion induces adipose browning and weight loss in mice, mediated by noradrenaline signaling via β3-adrenergic receptors, without requiring UCP1.
Nature Metabolism · Jun 3, 2025Peer-reviewedPhysiology