Rae Maeda

Cholesterol sulfate prevents maternal-fetal conflict by locally modulating immune reactivity

This study shows that cholesterol sulfate prevents maternal-fetal immune conflict by modulating immune reactivity in pregnant mice and humans.

Cysteine depletion triggers adipose tissue thermogenesis and weight-loss.

This study shows that cysteine depletion induces adipose browning and weight loss in mice, mediated by noradrenaline signaling via β3-adrenergic receptors, without requiring UCP1.

Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.

This study shows that elevated taurine reduces age-related inflammation by inhibiting the NLRP3 inflammasome and pyroptosis in mice.

Distinct classes of antidepressants commonly act to shape pallidal structure and function in mice

The paper shows that different antidepressants induce similar structural and molecular changes in the pallidum of mice, suggesting a common mechanism in their antidepressant effects.

Postnatal xanthine metabolism regulates cardiac regeneration in mammals

This study shows that postnatal xanthine metabolism regulates cardiac regeneration by linking redox state to cardiomyocyte proliferation and regenerative potential in mice.

Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild

This study identifies key yeast and bacterial species affecting Drosophila larval growth and shows their functional roles in gene regulation and metabolism.