Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes
Shane S. Kelly, Soumyadeep Sarkar, Sarai M. Williams, Aizhong Fu, Elizabeth Ashley Butterworth, Tyler J. Sagendorf, Lorenz A. Nierves, Yu Mi Kwon, Xiaolu Li, Vladislav Petyuk, Jing Chen, Ernesto Satoshi Nakayasu, Mark A. Atkinson, Rohit Kulkarni, Clayton E. Mathews, , Weijun Qian
The paper uses single-islet proteomics to analyze pseudo-temporal immune responses and beta-cell dysfunction in stage 1 T1D, identifying key pathways involved in islet dysfunction.
bioRxiv · Nov 10, 2025 · PreprintSystems Biology