Patricia Lemnitzer

Time-restricted feeding exacerbates liver fibrosis by promoting BDH1-mediated ketolysis in hepatic stellate cells.

This study shows that time-restricted feeding worsens liver fibrosis by increasing BDH1-mediated ketolysis in hepatic stellate cells.

CCR2+ neutrophils exhibit a proinflammatory phenotype and promote plaque destabilization

This study identifies CCR2+ neutrophils in atherosclerotic plaques that promote instability through ROS production and NET release, and shows that targeting CCR2 reduces plaque destabilization.

Divergent granulopoiesis at extramedullary sites safeguards host defense

This study shows that the spleen produces neutrophils with distinct differentiation trajectories during stress, which are functionally competent and necessary for host defense against bacterial infection.