CCR2+ neutrophils exhibit a proinflammatory phenotype and promote plaque destabilization
Merieme Farjia, Chang Pan, Quinte Braster, Patricia Lemnitzer, Nadja Sachs, Christian Schulz, Lars Mäegdefessel, Oliver Soehnlein, Carlos Silvestre-Roig
This study identifies CCR2+ neutrophils in atherosclerotic plaques that promote instability through ROS production and NET release, and shows that targeting CCR2 reduces plaque destabilization.
bioRxiv · Aug 6, 2025 · PreprintImmunology