Somenath Bakshi

The paper shows that population-level measurements of ribosome regulation during translation inhibition can be misleading due to growth-dependent reweighting and reporter distortion, highlighting the need for longitudinal sampling and validated reporter behavior.

This study uses time-lapse imaging to analyze phage infection dynamics in bacteria, revealing heterogeneity and its impact on phage fitness.

The paper identifies a transient tolerant state in resuscitating cells that enhances survival against beta-lactam antibiotics, driven by prior stress history and suboptimal dosing.

This paper uses agent-based simulations to show that lysis time variability in bacteriophages can provide a fitness advantage in competition, even when reducing growth rate in isolation.

This study identifies Tmn as a bacterial membrane protein that blocks phage spread by inducing plasmolysis and activates synergistic defence responses through ATP depletion.

This paper presents a microfluidic imaging platform to study efflux pump heterogeneity and antibiotic response in E. coli at single-cell resolution.

This study shows that protein synthesis, particularly ribosome dynamics, enhances fluidity in bacterial cytoplasm by counteracting its glassy nature through metabolic activity.

This study uses a synthetic gene oscillator to analyze bacterial growth dynamics in the gut under healthy and inflammatory conditions, revealing variability in single-cell behavior.

The paper quantifies very low-abundant proteins in bacteria using HaloTag and epifluorescence microscopy, achieving ≥80% detection efficiency.