A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Matthew A. Simon, Jiping Yang, Jonathan Gigas, Eric J. Earley, Eric C. Hillpot, Lei Justan Zhang, Maria Zagorulya, Greg Tombline, Michael B. Gilbert, Samantha L. Yuen, Alexis Pope, Michael Van Meter, Stephan Emmrich, Denis Firsanov, Advait Athreya, , Vera A. Gorbunova
The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.
The EMBO Journal · Oct 10, 2022Peer-reviewedMolecular Biology