Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammation
Jiping Yang, Archana Tare, Lei Justan Zhang, Seungsoo Kim, Seungjin Ryu, Qinghua Guo, Yizhou Zhu, Xizhe Wang, Xifan Wang, Adam D. Hudgins, Di Guan, Chen Jin, Hyun‐Kyung Chang, Gil Atzmon, Sofiya Milman, , Yousin Suh
The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.
bioRxiv · May 17, 2023 · PreprintGenetics