β-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents
Graydon B. Gereau, Diana Zhou, Kalynn J. Van Voorhies, Ryan E. Tyler, Jeffrey Campbell, Jackson G. Murray, Ali Alvarez-Pamir, Luke A. Wykoff, Michel A. Companion, Michael R. C. Jackson, Steven H. Olson, Larry S. Barak, Lauren M. Slosky, Ryan P. Vetreno, Joyce Besheer, Zoé A. McElligott
This study evaluates the effects of SBI-553, a β-arrestin-biased allosteric modulator of NTSR1, on ethanol-related behaviors in rodents, finding reduced ethanol consumption and altered sensitivity to ethanol effects.
Addiction Neuroscience · Nov 2, 2024Peer-reviewedNeuroscience