Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection
Trever T. Greene, Yeara Jo, Carolina Chiale, Mónica Macal, Ziyan Fang, Fawziyah S. Khatri, Alicia L Codrington, Katelynn R. Kazane, Elizabeth Akbulut, Shobha Swaminathan, Yu Fujita, Patricia A. Fitzgerald-Bocarsly, Thekla Cordes, Christian M. Metallo, David A. Scott, Elina I. Zúñiga
This study identifies LDHB as a key regulator of pDC IFN-I production and metabolic capacity during viral infection, linking metabolic deficiencies to pDC exhaustion and its dual role in immunity and pathology.
Nature Communications · Feb 7, 2025Peer-reviewedImmunology